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BRENDA support

Literature summary extracted from

  • Wong, L.J.; Patton, W.F.
    Salt inhibition of nuclear histone acetyltransferase from calf thymus (1985), Int. J. Biochem., 17, 123-126.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.48 (NH4)2SO4 competitive against both acetyl-CoA and histones Bos taurus
2.3.1.48 additional information monovalent cations cause a 50% decrease in activity at an average concentration of 51 mM, divalent cations at 15 mM Bos taurus
2.3.1.48 Na+ competitive against both acetyl-CoA and histones Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.48 Bos taurus
-
calf
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.48 thymus
-
Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.48 acetyl-CoA + histone
-
Bos taurus CoA + acetylhistone
-
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Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.3.1.48 8
-
(NH4)2SO4 versus acetyl-CoA Bos taurus
2.3.1.48 12
-
(NH4)2SO4 versus histone Bos taurus
2.3.1.48 30
-
Na+ versus acetyl-CoA Bos taurus
2.3.1.48 34
-
Na+ versus histone Bos taurus