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Literature summary extracted from

  • Libby, P.R.
    Rat liver nuclear N-acetyltransferases: separation of two enzymes with both histone and spermidine acetyltransferase activity (1980), Arch. Biochem. Biophys., 203, 384-389.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.48 DNA in vitro, enzyme form A inhibited, enzyme form B relatively insensitive Rattus norvegicus
2.3.1.48 EDTA high concentrations Rattus norvegicus
2.3.1.48 histone inhibits spermidine acetylation, enzyme forms A and B Rattus norvegicus
2.3.1.48 spermidine inhibits histone acetylation at high concentrations, enzyme forms A and B Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.48 0.01
-
 acetyl-CoA + spermidine, enzyme form B Rattus norvegicus
2.3.1.48 0.015
-
 acetyl-CoA + spermidine, enzyme form A Rattus norvegicus
2.3.1.48 0.18
-
 spermidine enzyme form B Rattus norvegicus
2.3.1.48 0.27
-
 spermidine enzyme form A Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.48 nucleus enzyme form A and B Rattus norvegicus 5634
-

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.48 Rattus norvegicus
-
 2 enzyme forms: A and B
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.48 partial, enzyme forms A and B Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.48 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.48 0.00186
-
 enzyme form B Rattus norvegicus
2.3.1.48 0.00196
-
 enzyme form A Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.48 acetyl-CoA + 1,4-butanediamine enzyme form A and B, low activity Rattus norvegicus ?
-
 ?
2.3.1.48 acetyl-CoA + 1,4-butanediamine i.e. putrescine Rattus norvegicus ?
-
 ?
2.3.1.48 acetyl-CoA + 1,5-pentanediamine enzyme form A and B, low activity Rattus norvegicus ?
-
 ?
2.3.1.48 acetyl-CoA + 1,5-pentanediamine i.e. cadaverine Rattus norvegicus ?
-
 ?
2.3.1.48 acetyl-CoA + 1,6-hexanediamine enzyme form A shows low activity , B not Rattus norvegicus ?
-
 ?
2.3.1.48 acetyl-CoA + histone histone H1 poor substrate Rattus norvegicus CoA + acetylhistone
-
 ?
2.3.1.48 acetyl-CoA + histone H1 histone H1 poor substrate Rattus norvegicus CoA + acetylhistone H1
-
 ?
2.3.1.48 acetyl-CoA + histone H3 histone H3: preferred substrate Rattus norvegicus CoA + acetylhistone H3
-
 ?
2.3.1.48 acetyl-CoA + histone H4 histone H4 is a poor substrate Rattus norvegicus CoA + acetylhistone H4
-
 ?
2.3.1.48 acetyl-CoA + spermidine
-
 Rattus norvegicus ?
-
 ?
2.3.1.48 acetyl-CoA + spermine
-
 Rattus norvegicus ?
-
 ?
2.3.1.48 additional information diaminodipropylamine and 1,3-propanediamine are no substrates Rattus norvegicus ?
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.48 7.8
-
 enzyme form B, substrate histone Rattus norvegicus
2.3.1.48 7.8 8.8 enzyme form B, substrate spermidine Rattus norvegicus
2.3.1.48 8.5 8.8 enzyme form A, substrate spermidine Rattus norvegicus
2.3.1.48 8.8
-
 enzyme form A, substrate histine Rattus norvegicus