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Literature summary extracted from

  • Otsuka, A.J.; Buoncristiani, M.R.; Howard, P.K.; Flamm, J.; Johnson, C.; Yamamoto, R.; Uchida, K.; Cook, C.; Ruppert, J.; Matsuzaki, J.
    The Escherichia coli biotin biosynthetic enzyme sequences predicted from the nucleotide sequence of the bio operon (1988), J. Biol. Chem., 263, 19577-19585.
    View publication on PubMed

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.1.1.197 28322
-
 x * 28322, calculated Escherichia coli
2.3.1.47 additional information
-
 amino acid sequence Escherichia coli
2.3.1.47 41600
-
 calculated from nucleotide sequence Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.47 6-carboxyhexanoyl-CoA + L-alanine Escherichia coli i.e. pimeloyl-CoA 8-amino-7-oxononanoate + CoA + CO2 i.e. 7-oxo-8-amino-pelargonic acid ir
2.3.1.47 6-carboxyhexanoyl-CoA + L-alanine Escherichia coli reaction in biotin biosynthesis 8-amino-7-oxononanoate + CoA + CO2 i.e. 7-oxo-8-amino-pelargonic acid ir

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.197 Escherichia coli P12999
-
-
2.3.1.47 Escherichia coli
-
 gene bioF
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.47 6-carboxyhexanoyl-CoA + L-alanine i.e. pimeloyl-CoA Escherichia coli 8-amino-7-oxononanoate + CoA + CO2 i.e. 7-oxo-8-amino-pelargonic acid ir
2.3.1.47 6-carboxyhexanoyl-CoA + L-alanine reaction in biotin biosynthesis Escherichia coli 8-amino-7-oxononanoate + CoA + CO2 i.e. 7-oxo-8-amino-pelargonic acid ir

Subunits

EC Number Subunits Comment Organism
2.1.1.197 ? x * 28322, calculated Escherichia coli

Synonyms

EC Number Synonyms Comment Organism
2.3.1.47 7-KAP synthetase
-
 Escherichia coli

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.47 additional information
-
 pI: 7.0 Escherichia coli

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.3.1.47 6.3 7.6
-
 Escherichia coli

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.47 pyridoxal 5'-phosphate
-
 Escherichia coli

pI Value

EC Number Organism Comment pI Value Maximum pI Value
2.1.1.197 Escherichia coli calculated
-
 9.4

Expression

EC Number Organism Comment Expression
2.1.1.197 Escherichia coli the biotin operon contains the five biotin operon genes, bioA, B, F, C, and D, and an open reading frame of unknown function. The operon is negatively regulated and divergently transcribed from a control region between the bioA and bioB genes additional information