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Literature summary extracted from

  • Diaz, S.; Higa, H.H.; Varki, A.
    Glycoprotein sialate 7(9)-O-acetyltransferase from rat liver Golgi vesicles (1989), Methods Enzymol., 179, 416-422.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.45 CoA inhibition of transfer to endogenous acceptors, no inhibition of transfer from acetyl intermediate to free acetylneuraminate Rattus norvegicus
2.3.1.45 diethyl dicarbonate
-
Rattus norvegicus
2.3.1.45 N-bromosuccinimide
-
Rattus norvegicus
2.3.1.45 Triton X-100 above 0.02% Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.45 0.0028
-
acetyl-CoA cosubstrate glycosidically bound N-acetylneuraminate Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.45 cytosol equally distributed between membrane and cytosolic fraction Rattus norvegicus 5829
-
2.3.1.45 Golgi vesicle equally distributed between membrane and cytosolic fraction Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.45 acetyl-CoA + sialic acid Rattus norvegicus pathway, overview CoA + N-acetyl-7-O(or 9-O-)-acetylneuraminate
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.45 Rattus norvegicus
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.3.1.45 acetyl-CoA + N-acetylneuraminate = CoA + N-acetyl-7-O(or 9-O)-acetylneuraminate 7-O-acetyl groups can migrate to the 9-position Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.45 liver
-
Rattus norvegicus
-

Storage Stability

EC Number Storage Stability Organism
2.3.1.45 -70°C, prelabeled Golgi vesicles, 4 days Rattus norvegicus
2.3.1.45 frozen Golgi vesicles are stable for 3-6 months Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.45 acetyl-CoA + N-acetylneuraminate glycosidically bound N-acetylneuraminate Rattus norvegicus CoA + N-acetyl-7-O(or 9-O-)-acetylneuraminate
-
?
2.3.1.45 acetyl-CoA + N-acetylneuraminate acetylneuraminate bound to sialic acids Rattus norvegicus CoA + N-acetyl-7-O(or 9-O-)-acetylneuraminate
-
?
2.3.1.45 acetyl-CoA + N-acetylneuraminate free acetylneuraminate Rattus norvegicus CoA + N-acetyl-7-O(or 9-O-)-acetylneuraminate
-
?
2.3.1.45 acetyl-CoA + sialic acid pathway, overview Rattus norvegicus CoA + N-acetyl-7-O(or 9-O-)-acetylneuraminate
-
?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.45 6.5
-
assay at Rattus norvegicus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.3.1.45 0.00074
-
CoA
-
Rattus norvegicus