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Literature summary extracted from

  • Jonas, A.
    Lecithin cholesterol acyltransferase (2000), Biochim. Biophys. Acta, 1529, 245-256.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.43 apolipoprotein A-I
-
 Homo sapiens
2.3.1.43 apolipoprotein A-IV
-
 Homo sapiens
2.3.1.43 Apolipoprotein C-1
-
 Homo sapiens
2.3.1.43 apolipoprotein E
-
 Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.43 expression in mice and rabbit Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.43 additional information hydroperoxides of lecithin act as competitive inhibitors; LCAT may experience product inhibition Homo sapiens
2.3.1.43 sphingomyelin
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.43 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.3.1.43 glycoprotein removal of individual carbohydrate chains affects activity Homo sapiens
2.3.1.43 glycoprotein four N-glycosydation and two O-glycosylation sites attached to glycans Homo sapiens
2.3.1.43 glycoprotein human enzyme cloned in animal cells has different degree of glycosydation Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.43 plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.43 1-O-alkyl-2-acetyl-sn-glycerol-3-phosphocholine + H2O
-
 Homo sapiens 1-O-alkyl-2-lyso-sn-glycerol-3-phosphocholine + acetate
-
 ?
2.3.1.43 phosphatidylcholine + sterol phosphatidylethanolamine, dimethylphosphatidylethanolamine, lecithins containing different acyl chain lengths and degrees of saturation Homo sapiens 1-acylglycerophosphocholine + sterol ester
-
 r