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Literature summary extracted from

  • Subbaiah, P.V.
    Lysolecithin acyltransferase of human plasma: assay and characterization of enzyme activity (1986), Methods Enzymol., 129, 790-797.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.43 low-density lipoprotein required for acylation of lysolecithin Homo sapiens
2.3.1.43 Serum albumin activates LCAT activity Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.43 additional information heparin and serum albumin inhibit lysolecithin acyltransferase activity Homo sapiens
2.3.1.43 Serum albumin inhibits LAT activity Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.43 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.43 plasma
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.43 additional information
-
assay methods Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.43 1-acylglyceryl phosphorylcholine + lecithin transfer of an acyl group from a lecithin molecule to another on the low-density lipoprotein surface, lysolecithin acyltransferase activity Homo sapiens lecithin + 1-acylglyceryl phosphorylcholine
-
r
2.3.1.43 additional information mechanism of LAT reaction is similar to that of LCAT, probably involving an acyl-enzyme intermediate, 2-acyl isomers of lysolecithin and lysophosphatidylethanolamine can act as substrates in the LAT reaction Homo sapiens ?
-
?
2.3.1.43 phosphatidylcholine + sterol
-
Homo sapiens 1-acylglycerophosphocholine + sterol ester
-
r