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Literature summary extracted from

  • Paterniti, J.R.; Beattie, D.S.
    delta-Aminolevulinic acid synthetase from rat liver mitochondria. Purification and properties (1979), J. Biol. Chem., 254, 6112-6118.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.37 hemin feed-back inhibition Rattus norvegicus
2.3.1.37 monovalent cations in Mg2+-containing medium: Na+ or Li+ at 100 mM have no effect on activity, higher concentrations are totally inhibitory Rattus norvegicus
2.3.1.37 additional information presence of high salt concentration in the sample buffer and running buffer of aggregated enzyme preparation results in inactivation Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.37 5
-
 succinyl-CoA
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.37 mitochondrion
-
 Rattus norvegicus 5739
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.3.1.37 Li+ in Mg2+-containing medium: at 100 mM no effect on activity, higher concentrations are totally inhibitory Rattus norvegicus
2.3.1.37 Na+ in Mg2+-containing medium: at 100 mM no effect on activity, higher concentrations are totally inhibitory Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.1.37 58000
-
 2 * 58000, mitochondria, SDS-PAGE Rattus norvegicus
2.3.1.37 120000
-
 gel filtration Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.37 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.37
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.37 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.37 0.035
-
 purified enzyme Rattus norvegicus

Storage Stability

EC Number Storage Stability Organism
2.3.1.37 -20°C, 20% loss of activity after 1 month Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.37 succinyl-CoA + glycine
-
 Rattus norvegicus 5-aminolevulinate + CoA + CO2
-
 ?

Subunits

EC Number Subunits Comment Organism
2.3.1.37 dimer 2 * 58000, mitochondria, SDS-PAGE Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.37 7.5
-
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.37 pyridoxal 5'-phosphate
-
 Rattus norvegicus