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Literature summary extracted from

  • Simpson, D.M.; Beattie, D.S.
    Purification of a specific activator of solubilized delta-aminolevulinic acid synthetase from rat liver mitochondria (1980), J. Biol. Chem., 255, 1630-1634.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.37 Activator protein from rat liver mitochondria possibly activates by formation of high molecular weight aggregates of delta-aminolevulinic acid synthetase Rattus norvegicus
2.3.1.37 native activator protein purified from hepatic extract Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.37 mitochondrion
-
 Rattus norvegicus 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.1.37 54000
-
 2 * 54000, SDS-PAGE Rattus norvegicus
2.3.1.37 58000
-
 monomer, gel filtration Rattus norvegicus
2.3.1.37 118000
-
 dimer, gel filtration Rattus norvegicus
2.3.1.37 218000
-
 tetramer of enzyme and native activator protein, gel filtration Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.37 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.37 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.37 succinyl-CoA + glycine
-
 Rattus norvegicus 5-aminolevulinate + CoA + CO2
-
 ?

Subunits

EC Number Subunits Comment Organism
2.3.1.37 dimer 2 * 54000, SDS-PAGE Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.37 additional information
-
 pI: 7.5 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.37 pyridoxal 5'-phosphate
-
 Rattus norvegicus