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Literature summary extracted from

  • Tait, G.H.
    Aminolaevulinate synthetase of Micrococcus denitrificans. Purification and properties of the enzyme, and the effect of growth conditions on the enzyme activity in cells (1973), Biochem. J., 131, 389-403.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.37 chloramphenicol
-
 Paracoccus denitrificans
2.3.1.37 hemin feed-back inhibition Paracoccus denitrificans
2.3.1.37 protoporphyrin
-
 Paracoccus denitrificans
2.3.1.37 puromycin
-
 Paracoccus denitrificans

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.37 0.01
-
 succinyl-CoA
-
 Paracoccus denitrificans
2.3.1.37 10
-
 succinyl-CoA
-
 Paracoccus denitrificans
2.3.1.37 12
-
 glycine
-
 Paracoccus denitrificans

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.1.37 68000
-
 gel filtration Paracoccus denitrificans

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.37 Paracoccus denitrificans
-
 in cells grown anaerobically and in iron-containing nitrate medium, overview
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.37 high activity in cells grown anaerobically in defined medium, low in cells grown in an iron-deficient medium and in cells grown aerobically Paracoccus denitrificans

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.37 cell culture high activity in cells grown anaerobically in defined medium, low in cells grown in an iron-deficient medium and in cells grown aerobically Paracoccus denitrificans
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.37 0.0037
-
 crude enzyme extract Paracoccus denitrificans
2.3.1.37 0.62
-
 purified enzyme Paracoccus denitrificans

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.37 succinyl-CoA + glycine
-
 Paracoccus denitrificans 5-aminolevulinate + CoA + CO2
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.37 7
-
 0.1 M phosphate buffer Paracoccus denitrificans
2.3.1.37 7.5
-
 0.1 M Tris-HCl buffer Paracoccus denitrificans

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.37 pyridoxal 5'-phosphate
-
 Paracoccus denitrificans