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Literature summary extracted from

  • Nozaki, T.; Shigeta, Y.; Saito-Nakano, Y.; Imada, M.; Kruger, W.D.
    Characterization of transsulfuration and cysteine biosynthetic pathways in the protozoan hemoflagellate, Trypanosoma cruzi. Isolation and molecular characterization of cystathionine b-synthase and serine acetyltransferase from Trypanosoma (2001), J. Biol. Chem., 276, 6516-6523.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.30 expression as glutathione-S-transferase fusion protein, amino acid sequence Trypanosoma cruzi

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.30 D-cysteine no inhibition Trypanosoma cruzi
2.3.1.30 glutathione weak, allosteric inhibition Trypanosoma cruzi
2.3.1.30 L-cysteine allosteric inhibition Trypanosoma cruzi
2.3.1.30 L-cystine allosteric inhibition Trypanosoma cruzi
2.3.1.30 L-homocysteine weak Trypanosoma cruzi
2.3.1.30 L-homoserine weak Trypanosoma cruzi
2.3.1.30 N-acetyl-L-cysteine weak Trypanosoma cruzi

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.30 0.24
-
 L-serine
-
 Trypanosoma cruzi
2.3.1.30 0.92
-
 acetyl-CoA
-
 Trypanosoma cruzi

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.1.30 38400
-
 x * 38400, amino acid sequence determination Trypanosoma cruzi

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.30 acetyl-CoA + L-serine Trypanosoma cruzi key role in the sulfur assimilatory pathway CoA + O-acetyl-L-serine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.30 Trypanosoma cruzi
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.30 acetyl-CoA + L-serine
-
 Trypanosoma cruzi CoA + O-acetyl-L-serine
-
 ?
2.3.1.30 acetyl-CoA + L-serine key role in the sulfur assimilatory pathway Trypanosoma cruzi CoA + O-acetyl-L-serine
-
 ?

Subunits

EC Number Subunits Comment Organism
2.3.1.30 ? x * 38400, amino acid sequence determination Trypanosoma cruzi

Synonyms

EC Number Synonyms Comment Organism
2.3.1.30 SAT
-
 Trypanosoma cruzi

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.3.1.30 0.012
-
 L-cysteine versus L-serine Trypanosoma cruzi
2.3.1.30 0.14
-
 L-cysteine versus acetyl-CoA Trypanosoma cruzi