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Literature summary extracted from

  • Leu, L.S.; Cook, P.F.
    Kinetic mechanism of serine transacetylase from Salmonella typhimurium (1994), Biochemistry, 33, 2667-2671.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.30 expression in Salmonella typhimurium Cys- strain DW 18.1 from plasmid Salmonella enterica subsp. enterica serovar Typhimurium

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.30 glycine competitive against L-serine, noncompetitive against acetyl-CoA Salmonella enterica subsp. enterica serovar Typhimurium
2.3.1.30 L-serine product inhibition, competitive against CoA and noncompetitive against O-acetyl-L-serine Salmonella enterica subsp. enterica serovar Typhimurium
2.3.1.30 O-acetyl-L-serine product inhibition, competitive against acetyl-CoA and noncompetitive against O-acetyl-L-serine Salmonella enterica subsp. enterica serovar Typhimurium
2.3.1.30 S-methyl-L-cysteine competitive against O-acetyl-L-serine, noncompetitive against CoA Salmonella enterica subsp. enterica serovar Typhimurium

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.30 acetyl-CoA + L-serine Salmonella enterica subsp. enterica serovar Typhimurium
-
 CoA + O-acetyl-L-serine
-
 r
2.3.1.30 acetyl-CoA + L-serine Salmonella enterica subsp. enterica serovar Typhimurium Cys- DW 18.1
-
 CoA + O-acetyl-L-serine
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.30 Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-
2.3.1.30 Salmonella enterica subsp. enterica serovar Typhimurium Cys- DW 18.1
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.30 recombinant Salmonella enterica subsp. enterica serovar Typhimurium

Reaction

EC Number Reaction Comment Organism Reaction ID
2.3.1.30 acetyl-CoA + L-serine = CoA + O-acetyl-L-serine ping pong bi bi mechanism Salmonella enterica subsp. enterica serovar Typhimurium
a

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.30 additional information
-
-
 Salmonella enterica subsp. enterica serovar Typhimurium

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.30 acetyl-CoA + L-serine
-
 Salmonella enterica subsp. enterica serovar Typhimurium CoA + O-acetyl-L-serine
-
 r
2.3.1.30 acetyl-CoA + L-serine equilibrium constant in direction of L-serine acetylation Salmonella enterica subsp. enterica serovar Typhimurium CoA + O-acetyl-L-serine
-
 r
2.3.1.30 acetyl-CoA + L-serine
-
 Salmonella enterica subsp. enterica serovar Typhimurium Cys- DW 18.1 CoA + O-acetyl-L-serine
-
 r
2.3.1.30 acetyl-CoA + L-serine equilibrium constant in direction of L-serine acetylation Salmonella enterica subsp. enterica serovar Typhimurium Cys- DW 18.1 CoA + O-acetyl-L-serine
-
 r

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.3.1.30 additional information
-
 additional information overview Salmonella enterica subsp. enterica serovar Typhimurium