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Literature summary extracted from

  • Sgoutas, D.S.
    Effect of geometry and position of ethylenic bond upon acyl coenzyme A: cholesterol-O-acyltransferase (1970), Biochemistry, 9, 1826-1833.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.26 0.0022
-
 elaidoyl-CoA
-
 Rattus norvegicus
2.3.1.26 0.0028
-
 linoleoyl-CoA
-
 Rattus norvegicus
2.3.1.26 0.004
-
 oleoyl-CoA
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.26 microsome
-
 Rattus norvegicus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.3.1.26 Mg2+ required for the acylation of free cholesterol Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.26 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.26 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.26 acyl-CoA + cholesterol acyl-CoA derivatives can be replaced by ATP, Mg2+, CoA and fatty acids, in-situ production of acyl-CoA Rattus norvegicus CoA + cholesterol ester
-
 ?
2.3.1.26 acyl-CoA + cholesterol the animal enzyme is highly specific for transfer of acyl groups with a single cis-double-bond 9 carbon atoms distant from the carboxyl group Rattus norvegicus CoA + cholesterol ester
-
 ?
2.3.1.26 elaidoyl-CoA + cholesterol
-
 Rattus norvegicus CoA + cholesteryl elaidate
-
 ?
2.3.1.26 linelaidoyl-CoA + cholesterol
-
 Rattus norvegicus CoA + cholesteryl linelaidate
-
 ?
2.3.1.26 linoleoyl-CoA + cholesterol
-
 Rattus norvegicus CoA + cholesteryl linoleate
-
 ?
2.3.1.26 oleoyl-CoA + cholesterol highest activity Rattus norvegicus CoA + cholesteryl oleate
-
 ?
2.3.1.26 palmitoyl-CoA + cholesterol
-
 Rattus norvegicus CoA + cholesteryl palmitate
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.26 37
-
 assay at Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.26 CoA required by the in-situ acyl-CoA production Rattus norvegicus