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Literature summary extracted from

  • Choy, P.C.; Tardi, P.G.; Mukherjee, J.J.
    Lysophosphatidylcholine acyltransferase (1992), Methods Enzymol., 209, 80-86.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.23 1-acyl-sn-glycero-3-phosphocholine
-
Oryctolagus cuniculus
2.3.1.23 1-acyl-sn-glycero-3-phosphocholine high concentration, lung enzyme Rattus norvegicus
2.3.1.23 Ca2+
-
Mammalia
2.3.1.23 Clofibric acid inhibition of mitochondrial enzyme Rattus norvegicus
2.3.1.23 Cyclic nucleotide phosphodiesterase inhibitors gastric mucosa microsomes Oryctolagus cuniculus
2.3.1.23 Cyclic nucleotide phosphodiesterase inhibitors liver and heart enzyme Rattus norvegicus
2.3.1.23 iodoacetate
-
Bos taurus
2.3.1.23 iodoacetate
-
Cavia porcellus
2.3.1.23 iodoacetate
-
Mammalia
2.3.1.23 iodoacetate
-
Oryctolagus cuniculus
2.3.1.23 iodoacetate liver enzyme Rattus norvegicus
2.3.1.23 Methyllidocaine inhibition of heart enzyme Mammalia
2.3.1.23 Mg2+
-
Mammalia
2.3.1.23 N-ethylmaleimide liver enzyme Rattus norvegicus
2.3.1.23 p-chloromercuriphenyl sulfonic acid liver enzyme Rattus norvegicus
2.3.1.23 WY-14643 inhibition of mitochondrial enzyme Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.23 0.00105 0.0057 acyl-CoA saturated and unsaturated acyl donors, human platelets Mammalia
2.3.1.23 0.0085
-
palmitoyl-CoA
-
Oryctolagus cuniculus
2.3.1.23 0.061
-
1-acyl-sn-glycero-3-phosphocholine
-
Oryctolagus cuniculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.23 membrane
-
Cavia porcellus 16020
-
2.3.1.23 membrane
-
Mammalia 16020
-
2.3.1.23 membrane
-
Bos taurus 16020
-
2.3.1.23 membrane
-
Oryctolagus cuniculus 16020
-
2.3.1.23 membrane plasma membrane Rattus norvegicus 16020
-
2.3.1.23 microsome
-
Cavia porcellus
-
-
2.3.1.23 microsome
-
Mammalia
-
-
2.3.1.23 microsome
-
Rattus norvegicus
-
-
2.3.1.23 microsome
-
Bos taurus
-
-
2.3.1.23 microsome
-
Oryctolagus cuniculus
-
-
2.3.1.23 mitochondrion
-
Cavia porcellus 5739
-
2.3.1.23 mitochondrion
-
Mammalia 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.1.23 43000
-
x * 43000, brain enzyme, SDS-PAGE Bos taurus
2.3.1.23 64000
-
x * 64000, heart enzyme, SDS-PAGE Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.23 Bos taurus
-
-
-
2.3.1.23 Cavia porcellus
-
-
-
2.3.1.23 Mammalia
-
-
-
2.3.1.23 Oryctolagus cuniculus
-
-
-
2.3.1.23 Rattus norvegicus
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.3.1.23 acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine = CoA + 1,2-diacyl-sn-glycero-3-phosphocholine lung enzyme displays an iso-ping-pong mechanism Oryctolagus cuniculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.23 brain
-
Rattus norvegicus
-
2.3.1.23 brain
-
Bos taurus
-
2.3.1.23 brain
-
Oryctolagus cuniculus
-
2.3.1.23 gastric mucosa
-
Oryctolagus cuniculus
-
2.3.1.23 liver
-
Cavia porcellus
-
2.3.1.23 liver
-
Mammalia
-
2.3.1.23 liver
-
Rattus norvegicus
-
2.3.1.23 liver
-
Bos taurus
-
2.3.1.23 liver
-
Oryctolagus cuniculus
-
2.3.1.23 lung
-
Rattus norvegicus
-
2.3.1.23 lung
-
Oryctolagus cuniculus
-
2.3.1.23 plasma
-
Rattus norvegicus
-
2.3.1.23 smooth muscle
-
Mammalia
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.23 0.013
-
acyl donor oleoyl-CoA, heart enzyme Rattus norvegicus
2.3.1.23 0.058
-
acyl donor oleoyl-CoA, liver enzyme Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.23 acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
-
Mammalia CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
r
2.3.1.23 acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
-
Bos taurus CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
r
2.3.1.23 acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
-
Oryctolagus cuniculus CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
r
2.3.1.23 acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine microsomal enzyme is more active toward unsaturated acyl-CoAs, the mitochondrial enzyme has a very high specificity toward linoleoyl-CoA Cavia porcellus CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
r
2.3.1.23 acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine specificity for acyl-CoA with unsaturated acyl groups, 1-palmitoyl-sn-glycero-3-phosphocholine is a better acceptor than 1-stearyl-sn-glycero-3-phosphocholine Rattus norvegicus CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
r
2.3.1.23 palmitoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
-
Oryctolagus cuniculus CoA + 1-acyl-2-palmitoyl-sn-glycero-3-phosphocholine
-
?

Subunits

EC Number Subunits Comment Organism
2.3.1.23 ?
-
Cavia porcellus
2.3.1.23 ?
-
Mammalia
2.3.1.23 ?
-
Rattus norvegicus
2.3.1.23 ?
-
Oryctolagus cuniculus
2.3.1.23 ? x * 43000, brain enzyme, SDS-PAGE Bos taurus
2.3.1.23 ? x * 64000, heart enzyme, SDS-PAGE Bos taurus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.23 25
-
assay at Cavia porcellus
2.3.1.23 25
-
assay at Mammalia
2.3.1.23 25
-
assay at Rattus norvegicus
2.3.1.23 25
-
assay at Bos taurus
2.3.1.23 25
-
assay at Oryctolagus cuniculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.23 7 8
-
Cavia porcellus
2.3.1.23 7 8
-
Rattus norvegicus
2.3.1.23 7 8
-
Bos taurus
2.3.1.23 7 8
-
Oryctolagus cuniculus
2.3.1.23 7 8 value depends on acyl donor Mammalia
2.3.1.23 7
-
-
Cavia porcellus
2.3.1.23 7
-
-
Bos taurus
2.3.1.23 7
-
transfer of oleoyl-CoA Rattus norvegicus
2.3.1.23 7
-
transfer of arachidonoyl-CoA is more rapid at a higher pH, liver enzyme Rattus norvegicus