EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
2.3.1.22 | bovine serum albumin | activation, liver, below 1 mg/ml, inhibitory above, not intestine | Rattus norvegicus | |
2.3.1.22 | deoxycholate | stimulates enzyme from intestinal mucosa | Rattus norvegicus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.3.1.22 | 2,4,6-Trinitrobenzene sulfonic acid | 3 mM, 80% inactivation of liver enzyme, 45% inactivation of intestinal enzyme, palmitate partly protects, enzyme from intestine is less sensitive than enzyme from liver | Rattus norvegicus | |
2.3.1.22 | 2-monooleoylglycerol | high concentration | Rattus norvegicus | |
2.3.1.22 | acetone | 10%, liver | Rattus norvegicus | |
2.3.1.22 | bovine serum albumin | activation below 1 mg/ml | Rattus norvegicus | |
2.3.1.22 | deoxycholate | inhibition of liver enzyme | Rattus norvegicus | |
2.3.1.22 | diethyldicarbonate | 0.04 mM, 50% inhibition, 0.05 mM palmitate partly protects, completely reversible by 50 mM hydroxylamine, enzyme from intestine is less sensitive than enzyme from liver | Rattus norvegicus | |
2.3.1.22 | EDTA | weak | Rattus norvegicus | |
2.3.1.22 | HgCl2 | weak | Rattus norvegicus | |
2.3.1.22 | MnCl2 | 2.5 mM, 86% inhibition of the intestinal enzyme, 40% inhibition of the enzyme from suckling liver | Rattus norvegicus | |
2.3.1.22 | palmitoyl-CoA | high concentration | Rattus norvegicus | |
2.3.1.22 | PCMB | - |
Rattus norvegicus | |
2.3.1.22 | taurocholate | - |
Rattus norvegicus | |
2.3.1.22 | Triton X-100 | - |
Rattus norvegicus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.3.1.22 | microsome | - |
Rattus norvegicus | - |
- |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.22 | acyl-CoA + sn-2-monoacylglycerol | Rattus norvegicus | involved in synthesis of triacylglycerols | CoA + diacylglycerol | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.3.1.22 | Rattus norvegicus | - |
Zivic Miller SD-strain | - |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.3.1.22 | liver | neonatal | Rattus norvegicus | - |
2.3.1.22 | additional information | tissue specific isozymes | Rattus norvegicus | - |
2.3.1.22 | small intestine mucosa | - |
Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.22 | acyl-CoA + sn-2-monoacylglycerol | involved in synthesis of triacylglycerols | Rattus norvegicus | CoA + diacylglycerol | - |
? | |
2.3.1.22 | fatty acyl-CoA + sn-2-monoacylglycerol | - |
Rattus norvegicus | CoA + 1,2-diacylglycerol | - |
? | |
2.3.1.22 | palmitoyl-CoA + rac-1-monooleoylglycerol | intestine, at 78% the rate of sn-2-monooleoylglycerol acylation | Rattus norvegicus | CoA + ? | - |
? | |
2.3.1.22 | palmitoyl-CoA + rac-1-monooleoylglycerol ether | intestine, at 45% the rate of sn-2-monooleoylglycerol acylation | Rattus norvegicus | CoA + ? | - |
? | |
2.3.1.22 | palmitoyl-CoA + sn-2-monooleoylglycerol | intestine, at 52% the rate of sn-2-monooleoylglycerol acylation | Rattus norvegicus | CoA + 1(3)-palmitoyl-2-oleoylglycerol | - |
? | |
2.3.1.22 | palmitoyl-CoA + sn-2-monooleoylglycerol | liver enzyme highly specific for sn-2-monooleoylglycerol | Rattus norvegicus | CoA + 1(3)-palmitoyl-2-oleoylglycerol | - |
? |
EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.3.1.22 | 48 | - |
12 min, microsomes from liver retain 90% of the initial activity | Rattus norvegicus |
2.3.1.22 | 51 | - |
12 min, microsomes from liver lose 23% of the initial activity, microsomes from intestinal mucosa lose 88.5% of control activity | Rattus norvegicus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.3.1.22 | 7 | 9 | - |
Rattus norvegicus |