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Literature summary extracted from

  • Finocchiaro, G.; Colombo, I.; DiDonato, S.
    Purification, characterization and partial amino acid sequences of carnitine palmitoyl-transferase from human liver (1990), FEBS Lett., 274, 163-166.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.21 malonyl-CoA no inhibition Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.21 additional information
-
 additional information Km values for carnitine with different acyl-CoA substrates Homo sapiens
2.3.1.21 0.011
-
 lauroyl-CoA
-
 Homo sapiens
2.3.1.21 0.0122
-
 palmitoyl-CoA
-
 Homo sapiens
2.3.1.21 0.017
-
 decanoyl-CoA
-
 Homo sapiens
2.3.1.21 0.018
-
 stearoyl-CoA
-
 Homo sapiens
2.3.1.21 0.023
-
 octanoyl-CoA
-
 Homo sapiens
2.3.1.21 0.031
-
 myristoyl-CoA
-
 Homo sapiens
2.3.1.21 0.123
-
 L-palmitoylcarnitine
-
 Homo sapiens
2.3.1.21 0.152
-
 hexanoyl-CoA
-
 Homo sapiens
2.3.1.21 1.139
-
 L-octanoylcarnitine
-
 Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.1.21 additional information
-
 amino acid sequence of peptides Homo sapiens
2.3.1.21 66000
-
 4 * 66000, SDS-PAGE Homo sapiens
2.3.1.21 274000
-
 gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.21 acyl-CoA + L-carnitine Homo sapiens enzyme has a key function in regulation of fatty acid beta-oxidation CoA + L-acylcarnitine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.21 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.21
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.21 liver
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.21 additional information
-
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.21 acyl-CoA + L-carnitine
-
 Homo sapiens CoA + L-acylcarnitine
-
 r
2.3.1.21 acyl-CoA + L-carnitine enzyme has a key function in regulation of fatty acid beta-oxidation Homo sapiens CoA + L-acylcarnitine
-
 ?
2.3.1.21 decanoyl-CoA + L-carnitine
-
 Homo sapiens CoA + L-decanoylcarnitine
-
 r
2.3.1.21 hexanoyl-CoA + L-carnitine
-
 Homo sapiens CoA + L-hexanoylcarnitine
-
 r
2.3.1.21 lauroyl-CoA + L-carnitine
-
 Homo sapiens CoA + L-lauroylcarnitine
-
 r
2.3.1.21 myristoyl-CoA + L-carnitine
-
 Homo sapiens CoA + L-myristoylcarnitine
-
 r
2.3.1.21 octanoyl-CoA + L-carnitine
-
 Homo sapiens CoA + L-octanoylcarnitine
-
 r
2.3.1.21 palmitoyl-CoA + L-carnitine
-
 Homo sapiens CoA + L-palmitoylcarnitine
-
 r
2.3.1.21 stearoyl-CoA + L-carnitine
-
 Homo sapiens CoA + L-stearoylcarnitine
-
 r

Subunits

EC Number Subunits Comment Organism
2.3.1.21 tetramer 4 * 66000, SDS-PAGE Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.21 25
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.21 8.5
-
-
 Homo sapiens