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Literature summary extracted from

  • Ramsay, R.R.; Derrick, J.P.; Friend, A.S.; Tubbs, P.K.
    Purification and properties of the soluble carnitine palmitoyltransferase from bovine liver mitochondria (1987), Biochem. J., 244, 271-278.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.21 11-trimethylamino-undecanoyl-DL-carnitine
-
 Bos taurus
2.3.1.21 2-bromoacetyl-CoA
-
 Bos taurus
2.3.1.21 2-bromopalmitoyl-CoA
-
 Bos taurus
2.3.1.21 2-[5(4-chlorophenyl)pentyl]-oxirane-2-carboxyl-CoA
-
 Bos taurus
2.3.1.21 bromoacetyl-CoA
-
 Bos taurus
2.3.1.21 malonyl-CoA
-
 Bos taurus
2.3.1.21 Tween 20
-
 Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.21 additional information
-
 additional information
-
 Bos taurus
2.3.1.21 0.0008
-
 palmitoyl-CoA with C8-CoA Bos taurus
2.3.1.21 0.0009
-
 decanoyl-CoA
-
 Bos taurus
2.3.1.21 0.0012
-
 myristoyl-CoA
-
 Bos taurus
2.3.1.21 0.0017
-
 stearoyl-CoA
-
 Bos taurus
2.3.1.21 0.0018
-
 hexanoyl-CoA
-
 Bos taurus
2.3.1.21 0.004
-
 dodecanoyl-CoA
-
 Bos taurus
2.3.1.21 0.0051
-
 butyryl-CoA
-
 Bos taurus
2.3.1.21 0.022
-
 acetyl-CoA
-
 Bos taurus
2.3.1.21 0.108
-
 L-carnitine with C8-CoA Bos taurus
2.3.1.21 0.12
-
 L-carnitine with C12-CoA Bos taurus
2.3.1.21 0.185
-
 L-carnitine with C16-CoA Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.21 mitochondrion
-
 Bos taurus 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.1.21 additional information
-
 amino acid composition Bos taurus
2.3.1.21 63500
-
 gel filtration, sucrose density gradient sedimentation Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.21 acyl-CoA + L-carnitine Bos taurus
-
 CoA + L-acylcarnitine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.21 Bos taurus
-
 ox
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.21
-
 Bos taurus

Reaction

EC Number Reaction Comment Organism Reaction ID
2.3.1.21 palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine rapid-equilibrium random-order mechanism Bos taurus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.21 liver
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.21 additional information
-
-
 Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.21 acetyl-CoA + L-carnitine
-
 Bos taurus CoA + L-acetylcarnitine
-
 ?
2.3.1.21 acyl-CoA + L-carnitine
-
 Bos taurus CoA + L-acylcarnitine
-
 ?
2.3.1.21 acyl-CoA + L-carnitine substrate specificity Bos taurus CoA + L-acylcarnitine
-
 ?
2.3.1.21 acyl-CoA + L-carnitine substrate specificity Bos taurus CoA + L-acylcarnitine
-
 r
2.3.1.21 butyryl-CoA + L-carnitine
-
 Bos taurus CoA + L-butyrylcarnitine
-
 ?
2.3.1.21 decanoyl-CoA + L-carnitine
-
 Bos taurus CoA + L-decanoylcarnitine
-
 ?
2.3.1.21 hexanoyl-CoA + L-carnitine
-
 Bos taurus CoA + L-hexanoylcarnitine
-
 ?
2.3.1.21 lauroyl-CoA + L-carnitine
-
 Bos taurus CoA + L-lauroylcarnitine
-
 ?
2.3.1.21 myristoyl-CoA + L-carnitine best substrate Bos taurus CoA + L-myristoylcarnitine
-
 ?
2.3.1.21 palmitoyl-CoA + L-carnitine best substrate Bos taurus CoA + L-palmitoylcarnitine
-
 r
2.3.1.21 stearoyl-CoA + L-carnitine
-
 Bos taurus CoA + L-stearoylcarnitine
-
 ?

Subunits

EC Number Subunits Comment Organism
2.3.1.21 monomer 1 * 63500, SDS-PAGE Bos taurus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.21 additional information
-
 pI: 6.0 Bos taurus
2.3.1.21 6 8.5
-
 Bos taurus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.3.1.21 0.00066
-
 2-bromopalmitoyl-CoA
-
 Bos taurus
2.3.1.21 0.17
-
 malonyl-CoA
-
 Bos taurus
2.3.1.21 0.2
-
 11-trimethylamino-undecanoyl-DL-carnitine
-
 Bos taurus
2.3.1.21 0.9
-
 2-bromoacetyl-CoA
-
 Bos taurus