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Literature summary extracted from

  • Carroll, M.A.; Morris, P.E.; Grosjean, C.D.; Anzalone, T.; Haldar, D.
    Further distinguishing properties of mitochondrial and microsomal glycerophosphate acyltransferase and the transmembrane location of the mitochondrial enzyme (1982), Arch. Biochem. Biophys., 214, 17-25.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.15 Polymyxin B activation of mitochondrial enzyme, inhibition of microsomal enzyme Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.15 Bromelain strong inhibition of microsomal enzyme Rattus norvegicus
2.3.1.15 deoxycholate
-
 Rattus norvegicus
2.3.1.15 additional information mitochondrial enzyme, not inhibited by bromelain, papain, pronase and trypsin Rattus norvegicus
2.3.1.15 papain strong inhibition of microsomal enzyme Rattus norvegicus
2.3.1.15 Polymyxin B 0.5 mg/ml, approx. 75% inhibition of microsomal enzyme, slight stimulation of mitochondrial enzyme Rattus norvegicus
2.3.1.15 Pronase strong inhibition of microsomal enzyme Rattus norvegicus
2.3.1.15 Triton X-100
-
 Rattus norvegicus
2.3.1.15 Trypsin 0.04 mg/ml, approx. 80% inhibition of microsomal enzyme within 3 min at 37°C, inhibition of the mitochondrial enzyme only in the presence of 0.05% deoxycholate or 0.1% Triton X-100 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.15 microsome
-
 Rattus norvegicus
-
-
2.3.1.15 mitochondrion
-
 Rattus norvegicus 5739
-

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.15 Rattus norvegicus
-
 male
-
2.3.1.15 Rattus norvegicus
-
 Sprague-Dawley strain
-
2.3.1.15 Rattus norvegicus Sprague-Dawley
-
 Sprague-Dawley strain
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.15 brain
-
 Rattus norvegicus
-
2.3.1.15 liver
-
 Rattus norvegicus
-

Storage Stability

EC Number Storage Stability Organism
2.3.1.15 4-6°C, microsomal enzyme, t1/2: 4 h Rattus norvegicus
2.3.1.15 4-6°C, mitochondrial enzyme, 4 h, no loss of activity Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.15 oleoyl-CoA + sn-glycerol 3-phosphate
-
 Rattus norvegicus CoA + 1-oleoyl-sn-glycerol 3-phosphate
-
 ?
2.3.1.15 oleoyl-CoA + sn-glycerol 3-phosphate
-
 Rattus norvegicus Sprague-Dawley CoA + 1-oleoyl-sn-glycerol 3-phosphate
-
 ?
2.3.1.15 palmitoyl-CoA + sn-glycerol 3-phosphate
-
 Rattus norvegicus CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
 ?
2.3.1.15 palmitoyl-CoA + sn-glycerol 3-phosphate
-
 Rattus norvegicus Sprague-Dawley CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
 ?