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Literature summary extracted from

  • Chung, C.D.; Bieber, L.L.
    Properties of the medium chain/long chain carnitine acyltransferase purified from rat liver microsomes (1993), J. Biol. Chem., 268, 4519-4524.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.137 Aminocarnitine
-
 Rattus norvegicus
2.3.1.137 D-carnitine
-
 Rattus norvegicus
2.3.1.137 etomoxiryl-CoA
-
 Rattus norvegicus
2.3.1.137 malonyl-CoA microsomal COT, no inhibition of the mitochondrial enzyme Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.137 cytosol
-
 Rattus norvegicus 5829
-
2.3.1.137 microsome
-
 Rattus norvegicus
-
-
2.3.1.137 mitochondrion
-
 Rattus norvegicus 5739
-
2.3.1.137 peroxisome
-
 Rattus norvegicus 5777
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.1.137 50000 55000 SDS-PAGE Rattus norvegicus
2.3.1.137 53000
-
 Western blot, polyclonal antibody reaction Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.137 acyl-CoA + L-carnitine Rattus norvegicus
-
 acyl-L-carnitine + CoA
-
 r
2.3.1.137 acyl-L-carnitine + CoA Rattus norvegicus
-
 acyl-CoA + L-carnitine
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.137 Rattus norvegicus
-
 rat
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.137
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.137 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.137 3-methylglutaryl-CoA + L-carnitine little capacity to use this substrate Rattus norvegicus 3-methylglutaryl-L-carnitine + CoA
-
 r
2.3.1.137 3-methylglutaryl-L-carnitine + CoA
-
 Rattus norvegicus 3-methylglutaryl-CoA + L-carnitine
-
 r
2.3.1.137 acyl-CoA + L-carnitine
-
 Rattus norvegicus acyl-L-carnitine + CoA
-
 r
2.3.1.137 acyl-L-carnitine + CoA
-
 Rattus norvegicus acyl-CoA + L-carnitine
-
 r
2.3.1.137 beta-hydroxy-beta-methylglutaryl-L-carnitine + CoA
-
 Rattus norvegicus beta-hydroxy-beta-methylglutaryl-CoA + L-carnitine
-
 r
2.3.1.137 decanoyl-CoA + L-carnitine
-
 Rattus norvegicus L-decanoyl-L-carnitine + CoA
-
 r
2.3.1.137 decanoyl-L-carnitine + CoA
-
 Rattus norvegicus decanoyl-CoA + L-carnitine
-
 r
2.3.1.137 pivaloyl-CoA + L-carnitine little capacity to use this substrate Rattus norvegicus L-pivaloyl-L-carnitine + CoA
-
 r
2.3.1.137 pivaloyl-L-carnitine + CoA
-
 Rattus norvegicus pivaloyl-CoA + L-carnitine
-
 r
2.3.1.137 valproyl-CoA + L-carnitine little capacity to use this substrate Rattus norvegicus L-valproyl-L-carnitine + CoA
-
 r
2.3.1.137 valproyl-L-carnitine + CoA
-
 Rattus norvegicus valproyl-CoA + L-carnitine
-
 r

Synonyms

EC Number Synonyms Comment Organism
2.3.1.137 COT
-
 Rattus norvegicus