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Literature summary extracted from

  • Webster, L.T.; Siddiqui, U.A.; Lucas, S.V.; Strong, J.M.; Mieyal, J.J.
    Identification of separate acyl-CoA:glycine and acyl-CoA:L-glutamine N-acyltransferase activities in mitochondrial fractions from liver of rhesus monkey and man (1976), J. Biol. Chem., 251, 3352-3358.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.68 benzoyl-CoA weak competitive Macaca mulatta
2.3.1.68 butyryl-CoA 0.4 mM, in presence of 100 mM L-glutamine, 50% loss of activity Macaca mulatta

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.13 0.003
-
 glycine acyl donor salicyl-CoA Macaca mulatta
2.3.1.13 0.006
-
 glycine acyl donor benzoyl-CoA Macaca mulatta
2.3.1.13 0.02
-
 benzoyl-CoA cosubstrate glycine Macaca mulatta
2.3.1.13 0.03
-
 salicyl-CoA cosubstrate glycine Macaca mulatta
2.3.1.13 0.5
-
 glycine acyl donor butyryl-CoA Macaca mulatta
2.3.1.13 0.7
-
 butyryl-CoA cosubstrate glycine Macaca mulatta
2.3.1.68 0.035
-
 phenylacetyl-CoA
-
 Macaca mulatta

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.13 mitochondrion
-
 Homo sapiens 5739
-
2.3.1.13 mitochondrion
-
 Macaca mulatta 5739
-
2.3.1.68 mitochondrion
-
 Homo sapiens 5739
-
2.3.1.68 mitochondrion
-
 Macaca mulatta 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.1.13 24000
-
 gel filtration Macaca mulatta

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.13 Homo sapiens
-
-
-
2.3.1.13 Macaca mulatta
-
-
-
2.3.1.68 Homo sapiens
-
-
-
2.3.1.68 Macaca mulatta
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.13
-
 Homo sapiens
2.3.1.13 ammonium sulfate, Bio-gel P-150 Macaca mulatta
2.3.1.68
-
 Homo sapiens
2.3.1.68
-
 Macaca mulatta

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.13 liver
-
 Homo sapiens
-
2.3.1.13 liver
-
 Macaca mulatta
-
2.3.1.68 liver
-
 Homo sapiens
-
2.3.1.68 liver
-
 Macaca mulatta
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.13 acyl-CoA + glycine the CoA derivatives of a number of aliphatic and aromatic acids, e.g. benzoyl-CoA and butyryl-CoA can act as acyl donor Homo sapiens CoA + N-acylglycine
-
 ?
2.3.1.13 acyl-CoA + glycine the CoA derivatives of a number of aliphatic and aromatic acids, e.g. benzoyl-CoA and butyryl-CoA can act as acyl donor Macaca mulatta CoA + N-acylglycine
-
 ?
2.3.1.13 acyl-CoA + glycine salicyl-CoA acts as acyl donor Homo sapiens CoA + N-acylglycine
-
 ?
2.3.1.13 acyl-CoA + glycine salicyl-CoA acts as acyl donor Macaca mulatta CoA + N-acylglycine
-
 ?
2.3.1.13 benzoyl-CoA + glycine
-
 Macaca mulatta CoA + N-benzoylglycine
-
 ?
2.3.1.13 butyryl-CoA + glycine
-
 Macaca mulatta CoA + N-butyrylglycine
-
 ?
2.3.1.13 salicyl-CoA + glycine
-
 Macaca mulatta CoA + salicyluric acid
-
 ?
2.3.1.68 indoleacetyl-CoA + L-glutamine
-
 Homo sapiens CoA + indoleacetyl-L-glutamine
-
 ?
2.3.1.68 indoleacetyl-CoA + L-glutamine
-
 Macaca mulatta CoA + indoleacetyl-L-glutamine
-
 ?
2.3.1.68 phenylacetyl-CoA + L-glutamine
-
 Homo sapiens CoA + phenylacetyl-L-glutamine
-
 ?
2.3.1.68 phenylacetyl-CoA + L-glutamine
-
 Macaca mulatta CoA + phenylacetyl-L-glutamine
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.13 8.4 8.6
-
 Homo sapiens
2.3.1.13 8.4 8.6
-
 Macaca mulatta

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.3.1.68 0.17
-
 benzoyl-CoA with phenylacetyl-CoA as substrate Macaca mulatta