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Literature summary extracted from

  • Odegaard, T.J.; Kaltashov, I.A.; Cotter, R.J.; Steeghs, L.; Van Der Ley, P.; Khan, S.; Maskell, D.J.; Raetz, C.R.H.
    Shortened hydroxyacyl chains on lipid A of Escherichia coli cells expressing a foreign UDP-N-acetylglucosamine O-acyltransferase (1997), J. Biol. Chem., 272, 19688-19696.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.129 expression in Escherichia coli Neisseria meningitidis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.129 (R)-3-hydroxytetradecanoyl-[acyl-carrier protein] + UDP-N-acetyl-alpha-D-glucosamine Escherichia coli
-
 [acyl-carrier protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetyl-alpha-D-glucosamine
-
 ?
2.3.1.129 (R)-3-hydroxytetradecanoyl-[acyl-carrier protein] + UDP-N-acetyl-alpha-D-glucosamine Neisseria meningitidis
-
 [acyl-carrier protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetyl-alpha-D-glucosamine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.129 Escherichia coli
-
-
-
2.3.1.129 Neisseria meningitidis
-
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.129 0.000055
-
 S)-3-hydroxymyristoyl-[acyl-carrier-protein] as substrate Neisseria meningitidis
2.3.1.129 0.000067
-
 S)-3-hydroxymyristoyl-[acyl-carrier-protein] as substrate Escherichia coli
2.3.1.129 0.00007
-
 S)-3-hydroxydecanoyl-[acyl-carrier-protein] as substrate Escherichia coli
2.3.1.129 0.000247
-
 S)-3-hydroxydecanoyl-[acyl-carrier-protein] as substrate Neisseria meningitidis
2.3.1.129 0.00139
-
 S)-3-hydroxylauroyl-[acyl-carrier-protein] as substrate Escherichia coli
2.3.1.129 0.00325
-
 S)-3-hydroxylauroyl-[acyl-carrier-protein] as substrate Neisseria meningitidis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.129 (R)-3-hydroxytetradecanoyl-[acyl-carrier protein] + UDP-N-acetyl-alpha-D-glucosamine
-
 Escherichia coli [acyl-carrier protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetyl-alpha-D-glucosamine
-
 ?
2.3.1.129 (R)-3-hydroxytetradecanoyl-[acyl-carrier protein] + UDP-N-acetyl-alpha-D-glucosamine
-
 Neisseria meningitidis [acyl-carrier protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetyl-alpha-D-glucosamine
-
 ?
2.3.1.129 (R,S)-3-hydroxydodecanoyl-[acyl-carrier protein] + UDP-N-acetyl-alpha-D-glucosamine
-
 Escherichia coli [acyl-carrier protein] + UDP-3-O-(3-hydroxydodecanoyl)-N-acetyl-alpha-D-glucosamine
-
 ?
2.3.1.129 (R,S)-3-hydroxydodecanoyl-[acyl-carrier protein] + UDP-N-acetyl-alpha-D-glucosamine
-
 Neisseria meningitidis [acyl-carrier protein] + UDP-3-O-(3-hydroxydodecanoyl)-N-acetyl-alpha-D-glucosamine
-
 ?
2.3.1.129 (R,S)-3-hydroxylauroyl-[acyl-carrier protein] + UDP-N-acetyl-alpha-D-glucosamine
-
 Escherichia coli [acyl-carrier protein] + UDP-3-O-(3-hydroxylauroyl)-N-acetyl-alpha-D-glucosamine
-
 ?
2.3.1.129 (R,S)-3-hydroxylauroyl-[acyl-carrier protein] + UDP-N-acetyl-alpha-D-glucosamine
-
 Neisseria meningitidis [acyl-carrier protein] + UDP-3-O-(3-hydroxylauroyl)-N-acetyl-alpha-D-glucosamine
-
 ?
2.3.1.129 (R,S)-3-hydroxymyristoyl-[acyl-carrier protein] + UDP-N-acetyl-alpha-D-glucosamine
-
 Escherichia coli [acyl-carrier protein] + UDP-3-O-(3-hydroxymyristoyl)-N-acetyl-alpha-D-glucosamine
-
 ?
2.3.1.129 (R,S)-3-hydroxymyristoyl-[acyl-carrier protein] + UDP-N-acetyl-alpha-D-glucosamine
-
 Neisseria meningitidis [acyl-carrier protein] + UDP-3-O-(3-hydroxymyristoyl)-N-acetyl-alpha-D-glucosamine
-
 ?
2.3.1.129 (R,S)-3-hydroxytetradecanoyl-[acyl-carrier protein] + UDP-N-acetyl-alpha-D-glucosamine
-
 Escherichia coli [acyl-carrier protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetyl-alpha-D-glucosamine
-
 ?
2.3.1.129 (R,S)-3-hydroxytetradecanoyl-[acyl-carrier protein] + UDP-N-acetyl-alpha-D-glucosamine
-
 Neisseria meningitidis [acyl-carrier protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetyl-alpha-D-glucosamine
-
 ?