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Literature summary extracted from

  • MacRae, T.H.
    Tubulin post-translational modifications (1997), Eur. J. Biochem., 244, 265-278.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.3.2.25
-
 Sus scrofa

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.108 Ca2+
-
 Chlamydomonas reinhardtii
6.3.2.25 L-Dopa
-
 Rattus norvegicus
6.3.2.25 L-Phe
-
 Rattus norvegicus
6.3.2.25 L-Phe
-
 Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.108 flagellum
-
 Chlamydomonas reinhardtii
-
-
2.3.1.108 microtubule
-
 Bos taurus 5874
-
2.3.1.108 microtubule 2fold preference for polymerized versus soluble tubulin Chlamydomonas reinhardtii 5874
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.3.2.25 KCl
-
 Sus scrofa
6.3.2.25 KCl required Rattus norvegicus
6.3.2.25 MgCl2
-
 Sus scrofa
6.3.2.25 MgCl2 required Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.1.108 62000
-
 most prominent polypeptide, SDS-PAGE Bos taurus
2.3.1.108 67000
-
 2 * 67000, SDS-PAGE Chlamydomonas reinhardtii
2.3.1.108 130000
-
 gel filtration Chlamydomonas reinhardtii
6.3.2.25 43425
-
 x * 43425, calculation from nucleotide sequence Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.108 acetyl-CoA + alpha-tubulin L-lysine Bos taurus
-
 CoA + alpha-tubulin N6-acetyl-L-lysine
-
 ?
2.3.1.108 acetyl-CoA + alpha-tubulin L-lysine Chlamydomonas reinhardtii post-translational modification of alpha-tubulin CoA + alpha-tubulin N6-acetyl-L-lysine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.108 Bos taurus
-
-
-
2.3.1.108 Chlamydomonas reinhardtii
-
-
-
6.3.2.25 Rattus norvegicus
-
-
-
6.3.2.25 Sus scrofa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.108 partial Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.108 brain
-
 Bos taurus
-
2.3.1.108 neuron
-
 Chlamydomonas reinhardtii
-
2.3.1.108 retina
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.108 acetyl-CoA + alpha-tubulin L-lysine
-
 Bos taurus CoA + alpha-tubulin N6-acetyl-L-lysine
-
 ?
2.3.1.108 acetyl-CoA + alpha-tubulin L-lysine alpha-tubulin from mouse is acetylated Chlamydomonas reinhardtii CoA + alpha-tubulin N6-acetyl-L-lysine
-
 ?
2.3.1.108 acetyl-CoA + alpha-tubulin L-lysine alpha-tubulin from Chlamydomonas is acetylated Chlamydomonas reinhardtii CoA + alpha-tubulin N6-acetyl-L-lysine
-
 ?
2.3.1.108 acetyl-CoA + alpha-tubulin L-lysine post-translational modification of alpha-tubulin Chlamydomonas reinhardtii CoA + alpha-tubulin N6-acetyl-L-lysine
-
 ?

Subunits

EC Number Subunits Comment Organism
2.3.1.108 dimer 2 * 67000, SDS-PAGE Chlamydomonas reinhardtii
6.3.2.25 monomer x * 43425, calculation from nucleotide sequence Sus scrofa