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Literature summary extracted from

  • Haas, D.; Leisinger, T.
    Multiple control of N-acetylglutamate synthetase from Pseudomonas aeruginosa: synergistic inhibition by acetylglutamate and polyamines (1974), Biochem. Biophys. Res. Commun., 60, 42-47.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.1 1,3-diaminopropane 10 mM, 88% inhibition in the presence of 0.5 mM N-acetyl-L-glutamate Pseudomonas aeruginosa
2.3.1.1 arginine 0.2 mM, 73% inhibition, 97% inhibition in the presence of 0.5 mM N-acetyl-L-glutamate Pseudomonas aeruginosa
2.3.1.1 cadaverine 10 mM, 80% inhibition in the presence of 0.5 mM N-acetyl-L-glutamate Pseudomonas aeruginosa
2.3.1.1 polyamines
-
 Pseudomonas aeruginosa
2.3.1.1 putrescine 10 mM, 74% inhibition in the presence of 0.5 mM N-acetyl-L-glutamate Pseudomonas aeruginosa
2.3.1.1 spermidine 1 mM, 78% inhibition in the presence of 0.5 mM N-acetyl-L-glutamate Pseudomonas aeruginosa
2.3.1.1 spermine 1 mM, 88% inhibition in the presence of 0.5 mM N-acetyl-L-glutamate Pseudomonas aeruginosa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.1 acetyl-CoA + L-glutamate Pseudomonas aeruginosa enzyme catalyzes the first step in the biosynthesis of arginine CoA + N-acetyl-L-glutamate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.1 Pseudomonas aeruginosa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.1 ammonium sulfate, hydroxyapatite, 10fold purification Pseudomonas aeruginosa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.1 acetyl-CoA + L-glutamate
-
 Pseudomonas aeruginosa CoA + N-acetyl-L-glutamate
-
 ?
2.3.1.1 acetyl-CoA + L-glutamate enzyme catalyzes the first step in the biosynthesis of arginine Pseudomonas aeruginosa CoA + N-acetyl-L-glutamate
-
 ?