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Literature summary extracted from

  • Walker, M.S.; Walker, J.B.
    Enzymic studies on the biosynthesis of streptomycin (1966), J. Biol. Chem., 241, 1262-1270.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.4.2 L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate Streptomyces griseus
-
 L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
 ?
2.1.4.2 L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate Streptomyces griseocarneus
-
 L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
 ?
2.1.4.2 L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate Streptomyces bluensis
-
 L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
 ?
2.1.4.2 L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate Streptomyces kanamyceticus
-
 L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
 ?
2.1.4.2 L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate Streptomyces bikiniensis biosynthesis of streptomycin L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
 ?
2.1.4.2 L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate Streptomyces griseus W4
-
 L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.4.2 no activity in Streptomyces griseus
-
-
-
2.1.4.2 no activity in Streptomyces griseus ATCC 10971
-
-
-
2.1.4.2 Streptomyces bikiniensis
-
 ATCC 11062
-
2.1.4.2 Streptomyces bluensis
-
 var. bluensis NRRL 2876
-
2.1.4.2 Streptomyces griseocarneus
-
 ATCC 12628
-
2.1.4.2 Streptomyces griseus
-
-
-
2.1.4.2 Streptomyces griseus
-
 ATCC 12475
-
2.1.4.2 Streptomyces griseus W4
-
-
-
2.1.4.2 Streptomyces kanamyceticus
-
 ATCC 12853
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.4.2
-
 Streptomyces bikiniensis
2.1.4.2
-
 Streptomyces bluensis

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.4.2 mycelium
-
 Streptomyces bikiniensis
-
2.1.4.2 mycelium
-
 Streptomyces griseocarneus
-
2.1.4.2 mycelium
-
 Streptomyces kanamyceticus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.4.2 arginine + 2-deoxystreptamine 6-phosphate
-
 Streptomyces bikiniensis N-amidino-2-deoxystreptamine 6-phosphate + ornithine
-
 ?
2.1.4.2 arginine + 2-deoxystreptamine 6-phosphate
-
 Streptomyces bluensis N-amidino-2-deoxystreptamine 6-phosphate + ornithine
-
 ?
2.1.4.2 arginine + scyllo-inosamine 4-phosphate
-
 Streptomyces bikiniensis ornithine + N-amidino-scyllo-inosamine-4-phosphate
-
 ?
2.1.4.2 arginine + scyllo-inosamine 4-phosphate reversibility of transamidinations with the monoamidinated inosamine phosphate has not yet been demonstrated Streptomyces bluensis ornithine + N-amidino-scyllo-inosamine-4-phosphate
-
 ?
2.1.4.2 arginine + streptamine 6-phosphate
-
 Streptomyces bluensis ornithine + N-amidinostreptamine 6-phosphate
-
 ?
2.1.4.2 L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate
-
 Streptomyces griseus L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
 ?
2.1.4.2 L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate
-
 Streptomyces griseocarneus L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
 ?
2.1.4.2 L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate
-
 Streptomyces bluensis L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
 ?
2.1.4.2 L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate
-
 Streptomyces kanamyceticus L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
 ?
2.1.4.2 L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate biosynthesis of streptomycin Streptomyces bikiniensis L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
 ?
2.1.4.2 L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate
-
 Streptomyces griseus W4 L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
 ?
2.1.4.2 L-arginine + 1-amino-1-deoxy-scyllo-inositol-4-phosphate
-
 Streptomyces griseus L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
 ?
2.1.4.2 L-arginine + 1-amino-1-deoxy-scyllo-inositol-4-phosphate
-
 Streptomyces bikiniensis L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
 ?
2.1.4.2 L-arginine + 1-amino-1-deoxy-scyllo-inositol-4-phosphate
-
 Streptomyces griseocarneus L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
 ?
2.1.4.2 L-arginine + 1-amino-1-deoxy-scyllo-inositol-4-phosphate
-
 Streptomyces bluensis L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
 ?
2.1.4.2 L-arginine + 1-amino-1-deoxy-scyllo-inositol-4-phosphate
-
 Streptomyces kanamyceticus L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
 ?
2.1.4.2 L-arginine + 1-amino-1-deoxy-scyllo-inositol-4-phosphate
-
 Streptomyces griseus W4 L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
 ?
2.1.4.2 streptidine phosphate + glycylglycine
-
 Streptomyces bikiniensis ?
-
 ?
2.1.4.2 streptidine phosphate + glycylglycine
-
 Streptomyces griseocarneus ?
-
 ?
2.1.4.2 streptidine phosphate + glycylglycine
-
 Streptomyces bluensis ?
-
 ?
2.1.4.2 streptidine phosphate + glycylglycine
-
 Streptomyces kanamyceticus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.4.2 arginine:Xamidinotransferase
-
 Streptomyces griseus