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Literature summary extracted from

  • Brewer, S.J.; Taylor, P.M.; Turner, M.K.
    An adenosine triphosphate-dependent carbamoylphosphate--3-hydroxymethylcephem O-carbamoyltransferase from Streptomyces clavuligerus (1980), Biochem. J., 185, 555-564.
    View publication on PubMedView publication on EuropePMC

General Stability

EC Number General Stability Organism
2.1.3.7 phosphate anions stabilize during purification Streptomyces clavuligerus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.3.7 (NH4)2SO4
-
Streptomyces clavuligerus
2.1.3.7 adenosine-alpha,beta-methylene triphosphate
-
Streptomyces clavuligerus
2.1.3.7 adenosine-beta,gamma-methylene triphosphate
-
Streptomyces clavuligerus
2.1.3.7 ATP above 1 mM Streptomyces clavuligerus
2.1.3.7 Ba2+ weak Streptomyces clavuligerus
2.1.3.7 Cu2+
-
Streptomyces clavuligerus
2.1.3.7 diphosphate
-
Streptomyces clavuligerus
2.1.3.7 Fe2+ weak Streptomyces clavuligerus
2.1.3.7 NaCl
-
Streptomyces clavuligerus
2.1.3.7 Pb2+ weak Streptomyces clavuligerus
2.1.3.7 Sn2+
-
Streptomyces clavuligerus
2.1.3.7 Zn2+
-
Streptomyces clavuligerus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.1.3.7 cytoplasm
-
Streptomyces clavuligerus 5737
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.1.3.7 Mg2+ activation, maximal activity in the presence of Mn2+ and ATP Streptomyces clavuligerus
2.1.3.7 Mn2+ activation, maximal activity in the presence of Mg2+ and ATP Streptomyces clavuligerus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.3.7 carbamoyl phosphate + a 3-hydroxymethyl ceph-3-em-4-carboxylate Streptomyces clavuligerus catalyzes the synthesis of a wide range of carbamoyloxymethylcephems, e.g. cefuroxime phosphate + a 3-carbamoyloxymethylcephem
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.1.3.7 Streptomyces clavuligerus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.3.7
-
Streptomyces clavuligerus

Storage Stability

EC Number Storage Stability Organism
2.1.3.7 -10°C, 50 mM phosphate buffer, pH 7.0, stable for several weeks Streptomyces clavuligerus
2.1.3.7 4°C, in the presence of ATP and carbamoyl phosphate, stable for at least 3 days Streptomyces clavuligerus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.3.7 carbamoyl phosphate + 7-aminodeacetylcephalosporanic acid
-
Streptomyces clavuligerus 7-beta-acylamino-3-carbamoyloxymethylcephem + phosphate
-
?
2.1.3.7 carbamoyl phosphate + 7beta-acylamino-3-hydroxymethylcephem
-
Streptomyces clavuligerus 7beta-acylamino-3-carbamoyloxymethylcephem + phosphate
-
?
2.1.3.7 carbamoyl phosphate + a 3-hydroxymethyl ceph-3-em-4-carboxylate catalyzes the synthesis of a wide range of carbamoyloxymethylcephems, e.g. cefuroxime Streptomyces clavuligerus phosphate + a 3-carbamoyloxymethylcephem
-
?
2.1.3.7 carbamoyl phosphate + decarbamoylcefuroxime
-
Streptomyces clavuligerus carbamoylcefuroxime + phosphate
-
?
2.1.3.7 carbamoyl phosphate + [3-hydroxymethyl]deacetylcephalosporin C ATP may be a substrate or an effector Streptomyces clavuligerus 7beta-(5-D-aminoadipamido)-3-carbamoyloxymethylceph-3-em-4-carboxylic acid + phosphate
-
?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.1.3.7 6.8
-
-
Streptomyces clavuligerus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.1.3.7 5.9 7.4 about 75% of maximal activity at pH 5.9 and 7.4 Streptomyces clavuligerus

Cofactor

EC Number Cofactor Comment Organism Structure
2.1.3.7 ATP activation, up to 1 mM, may be substrate or effector, maximal activity in the presence of Mg2+ and Mn2+ Streptomyces clavuligerus
2.1.3.7 dATP activation, can replace ATP to some extent Streptomyces clavuligerus