Literature summary extracted from

Tricot, C.; Villeret, V.; Sainz, G.; Dideberg, O.; Stalon, V.
Allosteric regulation in Pseudomonas aeruginosa catabolic ornithine carbamoyltransferase revisited: association of concerted homotropic cooperative interactions and local heterotropic effects (1998), J. Mol. Biol., 283, 695-704.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
2.1.3.3	AMP	-	Pseudomonas aeruginosa
2.1.3.3	arsenate	potent activator in the concentration range of 0-10 mM	Pseudomonas aeruginosa
2.1.3.3	phosphate	potent activator in the concentration range of 0-10 mM	Pseudomonas aeruginosa

Protein Variants

EC Number	Protein Variants	Comment	Organism
2.1.3.3	E105G	no cooperativity towards carbamoyl phosphate, follows Michaelis-Menten kinetics	Pseudomonas aeruginosa

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
2.1.3.3	spermidine	E105G mutant enzyme, competitive vs. carbamoylphosphate	Pseudomonas aeruginosa

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.1.3.3	Pseudomonas aeruginosa	-	catabolic ornithine carbamoyltransferase	-

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Release 2023.1 (January 2023)