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Literature summary extracted from

  • Pierson, D.L.; Cox, S.L.; Gilbert, B.E.
    Human ornithine transcarbamylase. Purification and characterization of the enzyme from normal liver and the liver of a Reyes syndrome patient (1977), J. Biol. Chem., 252, 6464-6469.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.3.3 L-2,4-diaminobutyric acid
-
 Homo sapiens
2.1.3.3 L-2-Amino-4-pentenoic acid
-
 Homo sapiens
2.1.3.3 L-2-aminobutyrate L-isomer Homo sapiens
2.1.3.3 L-leucine
-
 Homo sapiens
2.1.3.3 L-norvaline
-
 Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.1.3.3 36500
-
 3 * 36500, SDS-PAGE Homo sapiens
2.1.3.3 110000
-
 gel filtration Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.1.3.3 Homo sapiens
-
 normal liver enzyme and enzyme from a liver of a patient with Reye's syndrome
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.3.3 enzyme from normal liver and liver of a Reye's syndrome patient, DEAE-cellulose, hydroxylapatite, Sephadex G-200 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.3.3 liver
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.1.3.3 83.3
-
 enzyme from a liver of a Reye's syndrome patient Homo sapiens
2.1.3.3 86.5
-
 enzyme from normal liver Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.3.3 carbamoyl phosphate + L-ornithine
-
 Homo sapiens phosphate + L-citrulline
-
 ?

Subunits

EC Number Subunits Comment Organism
2.1.3.3 trimer 3 * 36500, SDS-PAGE Homo sapiens