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Literature summary extracted from

  • Marshall, M.; Cohen, P.P.
    Ornithine transcarbamylase from Streptococcus faecalis and bovine liver. II. Multiple binding sites for carbamyl-P and L-norvaline, correlation with steady state kinetics (1972), J. Biol. Chem., 247, 1654-1668.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.3.3 Carbamoyl phosphate
-
 Enterococcus faecalis
2.1.3.3 DL-2-Amino-5-hydroxypentanoic acid
-
 Bos taurus
2.1.3.3 DL-2-Amino-5-hydroxypentanoic acid
-
 Enterococcus faecalis
2.1.3.3 L-2,4-diaminobutyric acid
-
 Bos taurus
2.1.3.3 L-2,4-diaminobutyric acid
-
 Enterococcus faecalis
2.1.3.3 L-2-aminobutyrate L-isomer Bos taurus
2.1.3.3 L-2-aminobutyrate L-isomer Enterococcus faecalis
2.1.3.3 L-alanine
-
 Bos taurus
2.1.3.3 L-alanine
-
 Enterococcus faecalis
2.1.3.3 L-leucine
-
 Bos taurus
2.1.3.3 L-leucine
-
 Enterococcus faecalis
2.1.3.3 L-norleucine
-
 Bos taurus
2.1.3.3 L-norleucine
-
 Enterococcus faecalis
2.1.3.3 L-norvaline
-
 Bos taurus
2.1.3.3 L-norvaline
-
 Enterococcus faecalis
2.1.3.3 phosphate
-
 Enterococcus faecalis

Organism

EC Number Organism UniProt Comment Textmining
2.1.3.3 Bos taurus
-
-
-
2.1.3.3 Enterococcus faecalis
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.3.3 liver
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.3.3 carbamoyl phosphate + L-ornithine highly specific for L-ornithine at pH 8.0 Bos taurus phosphate + L-citrulline
-
 ?
2.1.3.3 carbamoyl phosphate + L-ornithine highly specific for L-ornithine at pH 8.0 Enterococcus faecalis phosphate + L-citrulline
-
 ?
2.1.3.3 carbamoyl phosphate + lysine at alkaline pH Bos taurus phosphate + homocitrulline
-
 ?
2.1.3.3 carbamoyl phosphate + lysine at alkaline pH Enterococcus faecalis phosphate + homocitrulline
-
 ?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.1.3.3 90
-
 L-citrulline
-
 Enterococcus faecalis
2.1.3.3 187
-
 ornithine
-
 Bos taurus
2.1.3.3 3400
-
 ornithine
-
 Enterococcus faecalis

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.1.3.3 7.1
-
 ornithine synthesis Enterococcus faecalis
2.1.3.3 8.4
-
-
 Enterococcus faecalis
2.1.3.3 8.5
-
-
 Bos taurus
2.1.3.3 8.5
-
 citrulline synthesis Enterococcus faecalis

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.1.3.3 additional information
-
 additional information Ki for norvaline varies with pH, carbamoyl phosphate or phosphate concentration Enterococcus faecalis
2.1.3.3 0.012
-
 Carbamoyl phosphate at 25°C and pH 8.4 Enterococcus faecalis
2.1.3.3 8
-
 phosphate at 25°C and pH 7.1 Enterococcus faecalis