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Literature summary extracted from

  • Jacobson, G.R.; Stark, G.R.
    Aspartate transcarbamylase of Escherichia coli. Mechanisms of inhibition and activation by dicarboxylic acids and other anions (1975), J. Biol. Chem., 250, 6852-6860.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.1.3.2 L-malate activation in presence of excess carbamoyl phosphate and limiting L-aspartate Escherichia coli
2.1.3.2 mesotartrate activation in presence of excess carbamoyl phosphate and limiting L-aspartate Escherichia coli
2.1.3.2 succinate activation in presence of excess carbamoyl phosphate and limiting L-aspartate Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.3.2 2,2-dimethylsuccinate
-
 Escherichia coli
2.1.3.2 acetate
-
 Escherichia coli
2.1.3.2 Cl-
-
 Escherichia coli
2.1.3.2 fumarate
-
 Escherichia coli
2.1.3.2 L-malate
-
 Escherichia coli
2.1.3.2 Maleate
-
 Escherichia coli
2.1.3.2 mesotartrate
-
 Escherichia coli
2.1.3.2 succinate
-
 Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.3.2 carbamoylphosphate + L-aspartate Escherichia coli
-
 phosphate + N-carbamoyl-L-aspartate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.3.2 Escherichia coli
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.3.2 carbamoyl phosphate + L-aspartate
-
 Escherichia coli phosphate + N-carbamoyl-L-aspartate
-
 ?
2.1.3.2 carbamoylphosphate + L-aspartate
-
 Escherichia coli phosphate + N-carbamoyl-L-aspartate
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.1.3.2 0.17
-
 Maleate inhibition of catalytic subunits, C3 Escherichia coli
2.1.3.2 0.7
-
 mesotartrate inhibition of catalytic subunits, C3 Escherichia coli
2.1.3.2 1.1
-
 chloride inhibition of catalytic subunits, C3 Escherichia coli
2.1.3.2 2.2
-
 2,2-dimethylsuccinate inhibition of catalytic subunits, C3 Escherichia coli
2.1.3.2 3.5
-
 succinate inhibition of catalytic subunits, C3 Escherichia coli
2.1.3.2 5.3
-
 fumarate inhibition of catalytic subunits, C3 Escherichia coli