BRENDA - Enzyme Database

Enzyme interactions involving T4 phage-coded thymidylate synthase and deoxycytidylate hydroxymethylase

Mathews, C.K.; Wheeler, L.J.; Ungermann, C.; Young, J.P.; Ray, N.B.; Adv. Exp. Med. Biol. 338, 563-570 (1993)

Data extracted from this reference:

Cloned(Commentary)
EC Number
Commentary
Organism
2.1.2.8
structural gene 42 encodes enzyme
Escherichia virus T4
Engineering
EC Number
Amino acid exchange
Commentary
Organism
2.1.2.8
additional information
gene 42 amber mutants synthesize truncated forms of enzyme
Escherichia virus T4
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.1.2.8
5,10-methylenetetrahydrofolate + H2O + deoxycytidylate
Escherichia virus T4
-
tetrahydrofolate + 5-hydroxymethyldeoxycytidylate
enzyme is responsible for production of 5-hydroxymethyl-dCMP found in the DNA of the phage
Escherichia virus T4
?
2.1.2.8
additional information
Escherichia virus T4
enzyme is part of the dNTP synthetase complex
?
-
-
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.1.2.8
Escherichia virus T4
-
Escherichia coli infected with bacteriophage T4
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.1.2.8
5,10-methylenetetrahydrofolate + H2O + deoxycytidylate
-
485788
Escherichia virus T4
tetrahydrofolate + 5-hydroxymethyldeoxycytidylate
-
485788
Escherichia virus T4
?
2.1.2.8
5,10-methylenetetrahydrofolate + H2O + deoxycytidylate
-
485788
Escherichia virus T4
tetrahydrofolate + 5-hydroxymethyldeoxycytidylate
enzyme is responsible for production of 5-hydroxymethyl-dCMP found in the DNA of the phage
485788
Escherichia virus T4
?
2.1.2.8
additional information
enzyme is part of the dNTP synthetase complex
485788
Escherichia virus T4
?
-
-
-
-
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
2.1.2.8
5,10-methylenetetrahydrofolate
-
Escherichia virus T4
2.1.2.8
tetrahydrofolate
-
Escherichia virus T4
Cloned(Commentary) (protein specific)
EC Number
Commentary
Organism
2.1.2.8
structural gene 42 encodes enzyme
Escherichia virus T4
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
2.1.2.8
5,10-methylenetetrahydrofolate
-
Escherichia virus T4
2.1.2.8
tetrahydrofolate
-
Escherichia virus T4
Engineering (protein specific)
EC Number
Amino acid exchange
Commentary
Organism
2.1.2.8
additional information
gene 42 amber mutants synthesize truncated forms of enzyme
Escherichia virus T4
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.1.2.8
5,10-methylenetetrahydrofolate + H2O + deoxycytidylate
Escherichia virus T4
-
tetrahydrofolate + 5-hydroxymethyldeoxycytidylate
enzyme is responsible for production of 5-hydroxymethyl-dCMP found in the DNA of the phage
Escherichia virus T4
?
2.1.2.8
additional information
Escherichia virus T4
enzyme is part of the dNTP synthetase complex
?
-
-
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.1.2.8
5,10-methylenetetrahydrofolate + H2O + deoxycytidylate
-
485788
Escherichia virus T4
tetrahydrofolate + 5-hydroxymethyldeoxycytidylate
-
485788
Escherichia virus T4
?
2.1.2.8
5,10-methylenetetrahydrofolate + H2O + deoxycytidylate
-
485788
Escherichia virus T4
tetrahydrofolate + 5-hydroxymethyldeoxycytidylate
enzyme is responsible for production of 5-hydroxymethyl-dCMP found in the DNA of the phage
485788
Escherichia virus T4
?
2.1.2.8
additional information
enzyme is part of the dNTP synthetase complex
485788
Escherichia virus T4
?
-
-
-
-