EC Number | Application | Comment | Organism |
---|---|---|---|
2.1.2.3 | medicine | - |
Gallus sp. |
2.1.2.3 | medicine | target for development of inhibitors with potential use as chemotherapeutic agents | Homo sapiens |
2.1.2.3 | medicine | potential target for development of antineoplastic drugs | Homo sapiens |
EC Number | Cloned (Comment) | Organism |
---|---|---|
2.1.2.3 | ATICcDNA cloned into a pET28a vector and transformed into Escherichia coli BL21.DE3 for overexpression | Gallus sp. |
EC Number | Crystallization (Comment) | Organism |
---|---|---|
2.1.2.3 | ATIC complex crystallized in monoclinic space group P2(1), a = 56.48 A, b = 107.88 A, c = 103.86 A and beta = 91.2° | Gallus sp. |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.1.2.3 | 4-amino-10-methylpteroylglutamic acid | methotrexate, non-competitive inhibitor | Gallus sp. | |
2.1.2.3 | 4-amino-10-methylpteroylglutamic acid | methotrexate, non-competitive inhibitor | Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.1.2.3 | 0.0168 | - |
5-aminoimidazole-4-carboxamide ribonucleotide | - |
Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.2.3 | 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide | Homo sapiens | penultimate and final steps in the de novo purine biosynthesis pathway | tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide | - |
r | |
2.1.2.3 | 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide | Gallus sp. | penultimate and final steps in the de novo purine biosynthesis pathway | tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide | - |
r |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.1.2.3 | Gallus sp. | - |
avian | - |
2.1.2.3 | Homo sapiens | - |
human | - |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.1.2.3 | - |
Gallus sp. |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.2.3 | 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide | penultimate and final steps in the de novo purine biosynthesis pathway | Homo sapiens | tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide | - |
r | |
2.1.2.3 | 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide | penultimate and final steps in the de novo purine biosynthesis pathway | Gallus sp. | tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide | - |
r | |
2.1.2.3 | additional information | in all organisms studied to date AICARFT activity is accompanied by inosine monophosphate cyclohydrolase located on the same polypeptide encoded by the purH gene | Homo sapiens | ? | - |
? | |
2.1.2.3 | additional information | in all organisms studied to date AICARFT activity is accompanied by inosine monophosphate cyclohydrolase located on the same polypeptide encoded by the purH gene | Gallus sp. | ? | - |
? | |
2.1.2.3 | N10-formyltetrahydrofolic acid + 5-amino-4-imidazole carboxamide ribonucleotide | - |
Homo sapiens | tetrahydrofolic acid + 5-formamido-4-imidazole carboxamide ribonucleotide | - |
r | |
2.1.2.3 | N10-formyltetrahydrofolic acid + 5-amino-4-imidazole carboxamide ribonucleotide | - |
Gallus sp. | tetrahydrofolic acid + 5-formamido-4-imidazole carboxamide ribonucleotide | - |
r |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.1.2.3 | dimer | - |
Homo sapiens |
2.1.2.3 | dimer | - |
Gallus sp. |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.1.2.3 | N10-formyltetrahydrofolate | - |
Homo sapiens | |
2.1.2.3 | N10-formyltetrahydrofolate | - |
Gallus sp. |