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Literature summary extracted from

  • Ha, T.; Morgan, S.L.; Vaughn, W.H; Eto, I.; Baggott, J.E.
    Detection of inhibition of 5-aminoimidazole-4-carboxamide ribotide transformylase by thioinosinic acid and azathioprine by a new colorimetric assay (1990), Biochem. J., 272, 339-342.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.1.2.3 medicine
-
Homo sapiens
2.1.2.3 medicine
-
Gallus sp.
2.1.2.3 medicine animal model of systemic autoimmune disease Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.2.3 4-acetamidophenol
-
Gallus sp.
2.1.2.3 Azathioprine competitive inhibitor Gallus sp.
2.1.2.3 Azathioprine
-
Mus musculus
2.1.2.3 Ibuprofen anti-inflammatory drug Gallus sp.
2.1.2.3 Ibuprofen anti-inflammatory drug Mus musculus
2.1.2.3 naproxen anti-inflammatory drug Gallus sp.
2.1.2.3 naproxen anti-inflammatory drug Mus musculus
2.1.2.3 paracetamol
-
Gallus sp.
2.1.2.3 sulphalazine
-
Homo sapiens
2.1.2.3 thioinosinic acid competitive inhibitor Gallus sp.
2.1.2.3 thioinosinic acid
-
Mus musculus
2.1.2.3 tylenol
-
Gallus sp.

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.2.3 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide Mus musculus
-
tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide
-
r
2.1.2.3 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide Homo sapiens
-
tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide
-
r
2.1.2.3 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide Gallus sp.
-
tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide
-
r

Organism

EC Number Organism UniProt Comment Textmining
2.1.2.3 Gallus sp.
-
chicken
-
2.1.2.3 Homo sapiens
-
human
-
2.1.2.3 Mus musculus
-
mouse, strain MRL/lpr
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.2.3
-
Gallus sp.

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.2.3 liver
-
Homo sapiens
-
2.1.2.3 liver
-
Gallus sp.
-
2.1.2.3 lymphocyte
-
Homo sapiens
-
2.1.2.3 peripheral blood mononuclear cell
-
Mus musculus
-
2.1.2.3 peripheral blood mononuclear cell
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.2.3 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide
-
Mus musculus tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide
-
r
2.1.2.3 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide
-
Homo sapiens tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide
-
r
2.1.2.3 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide
-
Gallus sp. tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide
-
r
2.1.2.3 additional information in all organisms studied to date AICARFT activity is accompanied by inosine monophosphate cyclohydrolase located on the same polypeptide encoded by the purH gene Mus musculus ?
-
?
2.1.2.3 additional information in all organisms studied to date AICARFT activity is accompanied by inosine monophosphate cyclohydrolase located on the same polypeptide encoded by the purH gene Homo sapiens ?
-
?
2.1.2.3 additional information in all organisms studied to date AICARFT activity is accompanied by inosine monophosphate cyclohydrolase located on the same polypeptide encoded by the purH gene Gallus sp. ?
-
?
2.1.2.3 N10-formyltetrahydrofolic acid + 5-amino-4-imidazole carboxamide ribonucleotide
-
Mus musculus tetrahydrofolic acid + 5-formamido-4-imidazole carboxamide ribonucleotide
-
r
2.1.2.3 N10-formyltetrahydrofolic acid + 5-amino-4-imidazole carboxamide ribonucleotide
-
Homo sapiens tetrahydrofolic acid + 5-formamido-4-imidazole carboxamide ribonucleotide
-
r
2.1.2.3 N10-formyltetrahydrofolic acid + 5-amino-4-imidazole carboxamide ribonucleotide
-
Gallus sp. tetrahydrofolic acid + 5-formamido-4-imidazole carboxamide ribonucleotide
-
r

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.1.2.3 0.039
-
thioinosinic acid
-
Gallus sp.
2.1.2.3 0.09
-
Azathioprine
-
Mus musculus
2.1.2.3 0.11
-
thioinosinic acid
-
Mus musculus
2.1.2.3 0.12
-
Azathioprine
-
Gallus sp.