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Literature summary extracted from

  • Mueller, W.T.; Benkovic, S.J.
    On the purification and mechanism of action of 5-aminoimidazole-4-carboxamide-ribonucleotide transformylase from chicken liver (1981), Biochemistry, 20, 337-344.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.4.10 IMP minor 5% IMP contaminant in the substrate found to have no effects on the inosinicase assay Gallus gallus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.2.3 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide Mus musculus
-
 tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide
-
 r
2.1.2.3 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide Gallus sp.
-
 tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide
-
 r
3.5.4.10 5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide Gallus gallus de novo purine synthesis step 10 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.2.3 Gallus sp.
-
 chicken
-
2.1.2.3 Mus musculus
-
-
-
3.5.4.10 Gallus gallus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.2.3
-
 Mus musculus
2.1.2.3 inosinicase activity copurifies Gallus sp.
3.5.4.10 154-fold Gallus gallus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.2.3 Ehrlich ascites carcinoma cell
-
 Mus musculus
-
2.1.2.3 liver
-
 Gallus sp.
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.1.2.3 0.856
-
-
 Gallus sp.
3.5.4.10 5.09
-
 at 25°C Gallus gallus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.2.3 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide
-
 Mus musculus tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide
-
 r
2.1.2.3 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide
-
 Gallus sp. tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide
-
 r
2.1.2.3 additional information in all organisms studied to date AICARFT activity is accompanied by inosine monophosphate cyclohydrolase located on the same polypeptide encoded by the purH gene Mus musculus ?
-
 ?
2.1.2.3 additional information in all organisms studied to date AICARFT activity is accompanied by inosine monophosphate cyclohydrolase located on the same polypeptide encoded by the purH gene Gallus sp. ?
-
 ?
2.1.2.3 N10-formyltetrahydrofolic acid + 5-amino-4-imidazole carboxamide ribonucleotide
-
 Mus musculus tetrahydrofolic acid + 5-formamido-4-imidazole carboxamide ribonucleotide
-
 r
2.1.2.3 N10-formyltetrahydrofolic acid + 5-amino-4-imidazole carboxamide ribonucleotide
-
 Gallus sp. tetrahydrofolic acid + 5-formamido-4-imidazole carboxamide ribonucleotide
-
 r
3.5.4.10 5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide de novo purine synthesis step 10 Gallus gallus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.2.3 AICAR TFase
-
 Gallus sp.

Cofactor

EC Number Cofactor Comment Organism Structure
2.1.2.3 N10-formyltetrahydrofolate
-
 Gallus sp.