Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Baggott, J.E.; Krumdieck, C.L.
    Folylpoly-gamma-glutamates as cosubstrates of 10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazole-carboxamide formyltransferase (1979), Biochemistry, 18, 1037-1041.
No PubMed abstract available

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.1.2.3 ATIC complex crystallized in monoclinic space group P2(1), a = 56.48 A, b = 107.88 A, c = 103.86 A and beta = 91.2° Gallus sp.

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.1.2.3 0.00099
-
 N10-formyltetrahydropteroyltetraglutamate 25 mM KCl Gallus sp.
2.1.2.3 0.00107
-
 N10-formyltetrahydropteroyltetraglutamate 150 mM KCl Gallus sp.
2.1.2.3 0.00164
-
 N10-formyltetrahydropteroylhexaglutamate 25 mM KCl Gallus sp.
2.1.2.3 0.00165
-
 N10-formyltetrahydropteroylmonoglutamate 25 mM KCl Gallus sp.
2.1.2.3 0.00183
-
 N10-formyltetrahydropteroylheptaglutamate 25 mM KCl Gallus sp.
2.1.2.3 0.00195
-
 N10-formyltetrahydropteroylhexaglutamate 150 mM KCl Gallus sp.
2.1.2.3 0.00206
-
 N10-formyltetrahydropteroylpentaglutamate 150 mM KCl Gallus sp.
2.1.2.3 0.00256
-
 N10-formyltetrahydropteroylpentaglutamate 25 mM KCl Gallus sp.
2.1.2.3 0.00313
-
 N10-formyltetrahydropteroylheptaglutamate 150 mM KCl Gallus sp.
2.1.2.3 0.00595
-
 N10-formyltetrahydropteroyltriglutamate 150 mM KCl Gallus sp.
2.1.2.3 0.353
-
 N10-formyltetrahydropteroylmonoglutamate 150 mM KCl Gallus sp.
2.1.2.3 0.674
-
 N10-formyltetrahydropteroyltriglutamate 25 mM KCl Gallus sp.

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.1.2.3 K+ required for maximum enzymatic activity Gallus sp.

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.2.3 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide Gallus sp.
-
 tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide
-
 r
2.1.2.3 N10-formyltetrahydropteroylglutamate + 5'-phosphoribosyl-5-formamido-4-imidazole carboxamide ribonucleotide Gallus sp.
-
 tetrahydropteroylglutamate + 5'-phosphoribosyl-5-formamido-4-imidazole carboxamide
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.2.3 Gallus sp.
-
 chicken
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.2.3
-
 Gallus sp.

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.2.3 liver
-
 Gallus sp.
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.1.2.3 0.0371
-
-
 Gallus sp.

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.2.3 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide
-
 Gallus sp. tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide
-
 r
2.1.2.3 additional information in all organisms studied to date AICARFT activity is accompanied by inosine monophosphate cyclohydrolase located on the same polypeptide encoded by the purH gene Gallus sp. ?
-
 ?
2.1.2.3 N10-formyltetrahydrofolic acid + 5-amino-4-imidazole carboxamide ribonucleotide
-
 Gallus sp. tetrahydrofolic acid + 5-formamido-4-imidazole carboxamide ribonucleotide
-
 r
2.1.2.3 N10-formyltetrahydropteroylglutamate + 5'-phosphoribosyl-5-formamido-4-imidazole carboxamide ribonucleotide
-
 Gallus sp. tetrahydropteroylglutamate + 5'-phosphoribosyl-5-formamido-4-imidazole carboxamide ribonucleotide
-
 ?
2.1.2.3 N10-formyltetrahydropteroylglutamate + 5'-phosphoribosyl-5-formamido-4-imidazole carboxamide ribonucleotide
-
 Gallus sp. tetrahydropteroylglutamate + 5'-phosphoribosyl-5-formamido-4-imidazole carboxamide
-
 ?
2.1.2.3 N10-formyltetrahydropteroylglutamate + 5'-phosphoribosyl-5-formamino-4-imidazole carboxamide ribonucleotide
-
 Gallus sp. tetrahydropteroylglutamate + 5'-phosphoribosyl-5-formamido-4-imidazole carboxamide ribonucleotide
-
 ?
2.1.2.3 N10-formyltetrahydropteroylheptaglutamate + 5'-phosphoribosyl-5-formamino-4-imidazole carboxamide ribonucleotide
-
 Gallus sp. tetrahydropteroylglutamate + 5'-phosphoribosyl-5-formamido-4-imidazole carboxamide ribonucleotide
-
 ?
2.1.2.3 N10-formyltetrahydropteroylhexaglutamate + 5'-phosphoribosyl-5-formamino-4-imidazole carboxamide ribonucleotide
-
 Gallus sp. tetrahydropteroylglutamate + 5'-phosphoribosyl-5-formamido-4-imidazole carboxamide ribonucleotide
-
 ?
2.1.2.3 N10-formyltetrahydropteroylmonoglutamate + 5'-phosphoribosyl-5-formamino-4-imidazole carboxamide ribonucleotide
-
 Gallus sp. tetrahydropteroylmonoglutamate + 5'-phosphoribosyl-5-formamido-4-imidazole carboxamide ribonucleotide
-
 ?
2.1.2.3 N10-formyltetrahydropteroylpentaglutamate + 5'-phosphoribosyl-5-formamino-4-imidazole carboxamide ribonucleotide
-
 Gallus sp. tetrahydropteroylglutamate + 5'-phosphoribosyl-5-formamido-4-imidazole carboxamide ribonucleotide
-
 ?
2.1.2.3 N10-formyltetrahydropteroyltetraglutamate + 5'-phosphoribosyl-5-formamino-4-imidazole carboxamide ribonucleotide
-
 Gallus sp. tetrahydropteroylglutamate + 5'-phosphoribosyl-5-formamido-4-imidazole carboxamide ribonucleotide
-
 ?
2.1.2.3 N10-formyltetrahydropteroyltriglutamate + 5'-phosphoribosyl-5-formamino-4-imidazole carboxamide ribonucleotide
-
 Gallus sp. tetrahydorpteroylglutamate + 5'-phosphoribosyl-5-formamido-4-imidazole carboxamide ribonucleotide
-
 ?