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Literature summary extracted from

  • Hartman, S.C.; Buchanan, J.M.
    Biosynthesis of the purines. XXVI. The Identification of the formyl donors of the transformylation reactions (1959), J. Biol. Chem., 234, 1812-1816.
    View publication on PubMed

General Stability

EC Number General Stability Organism
2.1.2.3 much less stable during storage in maleate buffer than in Tris or phosphate solutions Gallus sp.

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.2.3 Cu2+
-
 Gallus sp.

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.2.2 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide Gallus gallus transformylation reaction of purine biosynthesis tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?
2.1.2.3 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide Gallus sp. precursors for inosinic acid biosynthesis tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.1.2.2 Gallus gallus
-
 chicken
-
2.1.2.3 Gallus sp.
-
 chicken
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.2.2
-
 Gallus gallus
2.1.2.3
-
 Gallus sp.

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.2.2 liver
-
 Gallus gallus
-

Storage Stability

EC Number Storage Stability Organism
2.1.2.3 2°C, if the solution of purified enzyme are stored for 3 or 4 months, a requirement for a specific formyl donor can then be shown Gallus sp.

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.2.2 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide
-
 Gallus gallus tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?
2.1.2.2 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide transformylation reaction of purine biosynthesis Gallus gallus tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?
2.1.2.2 N5,N10-anhydroformyltetrahydrofolic acid + glycinamide ribonucleotide
-
 Gallus gallus formylglycinamide ribonucleotide + ?
-
 ?
2.1.2.3 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide precursors for inosinic acid biosynthesis Gallus sp. tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide
-
 r
2.1.2.3 additional information in all organisms studied to date AICARFT activity is accompanied by inosine monophosphate cyclohydrolase located on the same polypeptide encoded by the purH gene Gallus sp. ?
-
 ?
2.1.2.3 N10-formyltetrahydrofolic acid + 5-amino-4-imidazole carboxamide ribonucleotide
-
 Gallus sp. tetrahydrofolic acid + 5-formamido-4-imidazole carboxamide ribonucleotide
-
 r
2.1.2.3 N5,N10-anhydroformyltetrahydrofolic acid + glycinamide ribonucleotide
-
 Gallus sp. N10-formyltetrahydrofolic acid + formylglycinamide ribonucleotide
-
 r
2.1.2.3 tetrahydrofolic acid + 5-formamido-4-imidazole carboxamide ribonucleotide
-
 Gallus sp. N10-formyltetrahydrofolic acid + 5-amino-4-imidazole carboxamide ribonucleotide
-
 r