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Literature summary extracted from

  • Antle, V.D.; Donat, N.; Hua, M.; Liao, P.L.; Vince, R.; Caperelli, C.A.
    Substrate specificity of human glycinamide ribonucleotide transformylase (1999), Arch. Biochem. Biophys., 370, 231-235.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.1.2.2 medicine
-
 Escherichia coli
2.1.2.2 medicine
-
 Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.2.2 cloned and expressed in Escherichia coli HMS174(DE3)/pCC12 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.2.2 2',3'-dideoxy-2',3'-didehydro-carbocyclic glycinamide ribonucleotide
-
 Homo sapiens
2.1.2.2 2',3'-dideoxy-carbocyclic glycinamide ribonucleotide
-
 Homo sapiens
2.1.2.2 5'-phosphonate carbocyclic glycinamide ribonucleotide
-
 Homo sapiens
2.1.2.2 5,10-dideazatetrahydrofolate
-
 Escherichia coli
2.1.2.2 5,10-dideazatetrahydrofolate
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.1.2.2 0.0011
-
 beta-glycinamide ribonucleotide
-
 Homo sapiens
2.1.2.2 0.0036
-
 carbocyclic beta-glycinamide ribonucleotide
-
 Homo sapiens
2.1.2.2 0.0101
-
 beta-glycinamide ribonucleotide
-
 Gallus gallus
2.1.2.2 0.0369
-
 carbocyclic beta-glycinamide ribonucleotide
-
 Gallus gallus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.2.2 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide Gallus gallus essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?
2.1.2.2 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide Escherichia coli essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?
2.1.2.2 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide Homo sapiens essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.2.2 Escherichia coli
-
-
-
2.1.2.2 Gallus gallus
-
 chicken
-
2.1.2.2 Homo sapiens
-
 human
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.2.2 recombinant enzyme, expressed in E. coli Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.2.2 liver
-
 Gallus gallus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.2.2 10-formyl-5,8-dideazafolate + carbocyclic beta-glycinamide ribonucleotide
-
 Escherichia coli 5,8-dideazafolate + N-formyl carbocyclic beta-glycinamide ribonucleotide
-
 ?
2.1.2.2 10-formyl-5,8-dideazafolate + carbocyclic beta-glycinamide ribonucleotide
-
 Homo sapiens 5,8-dideazafolate + N-formyl carbocyclic beta-glycinamide ribonucleotide
-
 ?
2.1.2.2 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide
-
 Gallus gallus tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?
2.1.2.2 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide
-
 Escherichia coli tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?
2.1.2.2 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide
-
 Homo sapiens tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?
2.1.2.2 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway Gallus gallus tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?
2.1.2.2 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway Escherichia coli tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?
2.1.2.2 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway Homo sapiens tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?
2.1.2.2 10-formyltetrahydrofolate + carbocyclic beta-glycinamide ribonucleotide
-
 Gallus gallus tetrahydrofolate + formyl glycinamide ribonucleotide
-
 ?
2.1.2.2 10-formyltetrahydrofolate + carbocyclic beta-glycinamide ribonucleotide
-
 Homo sapiens tetrahydrofolate + formyl glycinamide ribonucleotide
-
 ?
2.1.2.2 10-formyltetrahydrofolate + O-phosphonate carbocyclic glycinamide ribonucleotide
-
 Homo sapiens tetrahydrofolate + O-phosphonate-ribosyl-N-formylglycinamide
-
 ?
2.1.2.2 additional information
-
 Gallus gallus ?
-
 ?
2.1.2.2 additional information
-
 Escherichia coli ?
-
 ?
2.1.2.2 additional information alpha-glycinamide ribonucleotide and glycinamide ribonucleotide nucleoside are neither substrates for no inhibitors Homo sapiens ?
-
 ?