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Literature summary extracted from

  • Warren, M.S.; Marolewski, A.E.; Benkovic, S.J.
    A rapid screen of active site mutants in glycinamide ribonucleotide transformylase (1996), Biochemistry, 35, 8855-8862.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.2.2 second GAR transformylase encoded by the Escherichia coli purT gene Escherichia coli

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.1.2.2
-
Escherichia coli

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.1.2.2 0.01
-
10-formyl-5,8-dideazafolate mutant H108A Escherichia coli
2.1.2.2 0.017
-
10-formyl-5,8-dideazafolate
-
Escherichia coli
2.1.2.2 0.018
-
beta-glycinamide ribonucleotide mutant H108Q Escherichia coli
2.1.2.2 0.019
-
beta-glycinamide ribonucleotide
-
Escherichia coli
2.1.2.2 0.024
-
10-formyl-5,8-dideazafolate mutant H108Q Escherichia coli
2.1.2.2 0.025
-
10-formyl-5,8-dideazafolate mutant D144A Escherichia coli
2.1.2.2 0.029
-
beta-glycinamide ribonucleotide mutant D144A Escherichia coli
2.1.2.2 0.054
-
beta-glycinamide ribonucleotide mutant H108A Escherichia coli
2.1.2.2 0.9
-
10-formyl-5,8-dideazafolate mutant N106G Escherichia coli

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.1.2.2 23240
-
-
Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.2.2 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide Bacillus subtilis
-
tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
?
2.1.2.2 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide Saccharomyces cerevisiae
-
tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
?
2.1.2.2 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide Gallus gallus essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
?
2.1.2.2 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide Drosophila melanogaster essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
?
2.1.2.2 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide Escherichia coli essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
?
2.1.2.2 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide Homo sapiens essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.1.2.2 Bacillus subtilis
-
-
-
2.1.2.2 Drosophila melanogaster
-
fruit fly
-
2.1.2.2 Escherichia coli
-
strains DH5alpha, BL21(DE3), TX680
-
2.1.2.2 Gallus gallus
-
chicken
-
2.1.2.2 Homo sapiens
-
human
-
2.1.2.2 Saccharomyces cerevisiae
-
yeast
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.2.2
-
Escherichia coli

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.2.2 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide
-
Gallus gallus tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
?
2.1.2.2 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide
-
Drosophila melanogaster tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
?
2.1.2.2 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide
-
Bacillus subtilis tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
?
2.1.2.2 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide
-
Escherichia coli tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
?
2.1.2.2 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide
-
Homo sapiens tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
?
2.1.2.2 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide
-
Saccharomyces cerevisiae tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
?
2.1.2.2 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway Gallus gallus tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
?
2.1.2.2 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway Drosophila melanogaster tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
?
2.1.2.2 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway Escherichia coli tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
?
2.1.2.2 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway Homo sapiens tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
?

Subunits

EC Number Subunits Comment Organism
2.1.2.2 monomer
-
Gallus gallus
2.1.2.2 monomer
-
Bacillus subtilis
2.1.2.2 monomer
-
Escherichia coli
2.1.2.2 monomer
-
Homo sapiens
2.1.2.2 monomer
-
Saccharomyces cerevisiae

Synonyms

EC Number Synonyms Comment Organism
2.1.2.2 purN transformylase
-
Escherichia coli

Cofactor

EC Number Cofactor Comment Organism Structure
2.1.2.2 10-formyl-5,8-dideazafolate
-
Escherichia coli
2.1.2.2 formate second GAR transformylase using formate and ATP in place of 10-formyltetrahydrofolate Escherichia coli
2.1.2.2 N10-formyltetrahydrofolate
-
Gallus gallus
2.1.2.2 N10-formyltetrahydrofolate
-
Escherichia coli