Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Caperelli, C.A.
    Mammalian glycinamide ribonucleotide transformylase. Kinetic mechanism and associated de novo purine biosynthesis activities (1989), J. Biol. Chem., 264, 5053-5057.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.1.2.2 medicine pharmacological importance, target enzyme for chemotherapy, development of novel antifolate drugs, to be used as anti-cancer drugs Mus musculus
2.1.2.2 medicine pharmacological importance, target enzyme for chemotherapy, development of novel antifolate drugs, to be used as anti-cancer drugs Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.2.2 10-Acetyl-5,8-dideazafolate
-
 Drosophila melanogaster
2.1.2.2 10-Acetyl-5,8-dideazafolate
-
 Homo sapiens
2.1.2.2 10-Acetyl-5,8-dideazafolate
-
 Mus musculus
2.1.2.2 5,10-dideazafolic acid
-
 Mus musculus
2.1.2.2 alpha,beta-hydroxyacetamideribonucleotide
-
 Mus musculus
2.1.2.2 alpha,beta-N-(hydroxyacetyl)-D-ribofuranosylamine
-
 Mus musculus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.1.2.2 110000
-
-
 Gallus gallus
2.1.2.2 112000
-
 HeLa and L1210 cells Homo sapiens
2.1.2.2 115000
-
-
 Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.2.2 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide Gallus gallus essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?
2.1.2.2 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide Drosophila melanogaster essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?
2.1.2.2 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide Mus musculus essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?
2.1.2.2 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide Homo sapiens essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.2.2 Drosophila melanogaster
-
 fruit fly
-
2.1.2.2 Gallus gallus
-
 chicken
-
2.1.2.2 Homo sapiens
-
 human
-
2.1.2.2 Mus musculus
-
 mouse
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.2.2
-
 Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.2.2 L-5178-Y cell murine lymphoma cell line Mus musculus
-
2.1.2.2 liver
-
 Gallus gallus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.2.2 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide
-
 Gallus gallus tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?
2.1.2.2 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide
-
 Drosophila melanogaster tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?
2.1.2.2 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide
-
 Mus musculus tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?
2.1.2.2 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide
-
 Homo sapiens tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?
2.1.2.2 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway Gallus gallus tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?
2.1.2.2 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway Drosophila melanogaster tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?
2.1.2.2 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway Mus musculus tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?
2.1.2.2 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway Homo sapiens tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?
2.1.2.2 10-formyltetrahydrofolate + carbocyclic beta-glycinamide ribonucleotide
-
 Gallus gallus tetrahydrofolate + formyl glycinamide ribonucleotide
-
 ?
2.1.2.2 10-formyltetrahydrofolate + carbocyclic beta-glycinamide ribonucleotide
-
 Mus musculus tetrahydrofolate + formyl glycinamide ribonucleotide
-
 ?
2.1.2.2 10-formyltetrahydrofolate + carbocyclic beta-glycinamide ribonucleotide
-
 Homo sapiens tetrahydrofolate + formyl glycinamide ribonucleotide
-
 ?