EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
2.1.2.2 | 55000 | - |
2 * 55000, SDS-PAGE, sucrose density ultracentrifugation, proteolytic cleavage | Gallus gallus |
2.1.2.2 | 110000 | - |
SDS-PAGE | Gallus gallus |
2.1.2.2 | 117000 | - |
ultracentrifugation | Gallus gallus |
2.1.2.2 | 140000 | - |
sucrose density ultracentrifugation | Gallus gallus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.2.2 | 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | Gallus gallus | essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
2.1.2.2 | 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | Mus musculus | essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.1.2.2 | Gallus gallus | - |
chicken | - |
2.1.2.2 | Mus musculus | - |
mouse | - |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.1.2.2 | - |
Gallus gallus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.1.2.2 | L-1210 cell | murine leukemia | Mus musculus | - |
2.1.2.2 | liver | - |
Gallus gallus | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
2.1.2.2 | 14.8 | - |
- |
Gallus gallus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.2.2 | (6R)-N10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | - |
Gallus gallus | (6R)-tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
2.1.2.2 | 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | - |
Gallus gallus | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
2.1.2.2 | 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | - |
Mus musculus | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
2.1.2.2 | 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway | Gallus gallus | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
2.1.2.2 | 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway | Mus musculus | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
2.1.2.2 | additional information | GAR transformylase activity copurifies with 5,10-methylene-, 5,10-methenyl, and 10-formyl-H4folate sythetase (combined) trifunctional enzyme, EC 6.3.4.3, EC 1.5.1.5 and EC 3.5.4.9 | Gallus gallus | ? | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.1.2.2 | dimer | homodimer | Gallus gallus |
2.1.2.2 | dimer | 2 * 55000, SDS-PAGE, sucrose density ultracentrifugation, proteolytic cleavage | Gallus gallus |
2.1.2.2 | monomer | - |
Mus musculus |
2.1.2.2 | monomer | 1 * 117000, ultracentrifugation | Gallus gallus |