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Literature summary extracted from

  • Almassy, R.J.; Janson, C.A.; Kann, C.C.; Hostomska, Z.
    Structures of apo and complexed Escherichia coli glycinamide ribonucleotide transformylase (1992), Proc. Natl. Acad. Sci. USA, 89, 6114-6118.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.1.2.2 medicine target for structure-based drug design Escherichia coli
2.1.2.2 medicine pharmacological importance, target enzyme for chemotherapy, development of novel antifolate drugs, to be used as anti-cancer drugs Mus musculus
2.1.2.2 medicine pharmacological importance, target enzyme for chemotherapy, development of novel antifolate drugs, to be used as anti-cancer drugs Escherichia coli

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.2.2 coding region of Escherichia coli GART amplified from chromosomal DNA with PCR method Escherichia coli

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.1.2.2 crystals grown at 20°C by hanging-drop vapor diffusion, space group C222, a = 140.9 A, b = 97.6 A, c = 102.4 Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.2.2 5,10-dideaza-5,6,7,8-tetrahydrofolate
-
 Escherichia coli
2.1.2.2 5,10-dideazatetrahydrofolate
-
 Escherichia coli
2.1.2.2 5,10-dideazatetrahydrofolate
-
 Mus musculus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.1.2.2 23240
-
 amino acid sequence, deduced from nucleotide sequence Escherichia coli
2.1.2.2 100000
-
-
 Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.2.2 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide Mus musculus essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?
2.1.2.2 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide Escherichia coli essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.2.2 Escherichia coli
-
-
-
2.1.2.2 Mus musculus
-
 mouse
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.2.2
-
 Escherichia coli

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.2.2 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide
-
 Mus musculus tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?
2.1.2.2 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide
-
 Escherichia coli tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?
2.1.2.2 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway Mus musculus tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?
2.1.2.2 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway Escherichia coli tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?
2.1.2.2 additional information
-
 Escherichia coli ?
-
 ?
2.1.2.2 additional information 3 activities in a multifunctional protein, posessing glycinamide ribonucleotide synthetase, glycinamide ribonucleotidetransformylase and aminoimidazole ribonucleotide synthetase Mus musculus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.2.2 GART
-
 Escherichia coli