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Literature summary extracted from

  • Smith, G.K.; Benkovic, P.A.; Benkovic, S.J.
    L(-)-10-formyltetrahydrofolate is the cofactor for glycinamide ribonucleotide transformylase from chicken liver (1981), Biochemistry, 20, 4034-4036.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.2.2 L-(+)-10-formyltetrahydrofolate excellent competitive inhibitor Gallus gallus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.1.2.2 0.00576
-
 L-(+)-5,10-methenyltetrahydrofolate
-
 Gallus gallus
2.1.2.2 0.00594
-
 L-(-)-10-formyltetrahydrofolate in absence of trifunctional protein Gallus gallus
2.1.2.2 0.00676
-
 L-(-)-10-formyltetrahydrofolate
-
 Gallus gallus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.2.2 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide Gallus gallus
-
 tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.2.2 Escherichia coli
-
-
-
2.1.2.2 Gallus gallus
-
 chicken
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.2.2 liver
-
 Gallus gallus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.2.2 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide
-
 Gallus gallus tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?
2.1.2.2 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide
-
 Escherichia coli tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
2.1.2.2 L-(+-)-5,10-methenyltetrahydrofolate
-
 Gallus gallus
2.1.2.2 L-(-)-10-formyltetrahydrofolate
-
 Gallus gallus
2.1.2.2 L-(-)-10-formyltetrahydrofolate
-
 Escherichia coli