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Literature summary extracted from

  • Warren, L.; Buchanan, J.M.
    Biosynthesis of the purines. XIX. 2-Amino-N-ribosylacetamide 5'-phosphate(glycinamide ribotide) transformylase (1957), J. Biol. Chem., 229, 613-626.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.1.2.2 glycine stimulatory effect Gallus gallus
2.1.2.2 histidine stimulatory effect Gallus gallus
2.1.2.2 tryptophan stimulatory effect Gallus gallus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.2.2 Cu2+
-
 Gallus gallus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.1.2.2 0.052
-
 glycinamide ribotide
-
 Gallus gallus
2.1.2.2 0.058
-
 N5,N10-anhydroformyl tetrahydrofolate
-
 Gallus gallus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.2.2 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide Gallus gallus
-
 tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?
2.1.2.2 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide Clostridium cylindrosporum
-
 tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?
2.1.2.2 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide Columba sp.
-
 tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.2.2 Clostridium cylindrosporum
-
-
-
2.1.2.2 Columba sp.
-
 pigeon
-
2.1.2.2 Gallus gallus
-
 chicken
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.2.2
-
 Gallus gallus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.2.2 liver
-
 Gallus gallus
-
2.1.2.2 liver
-
 Columba sp.
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.1.2.2 53.6
-
-
 Gallus gallus

Storage Stability

EC Number Storage Stability Organism
2.1.2.2 -10°C, 8months, no appreciable loss of activity Gallus gallus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.2.2 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide
-
 Gallus gallus tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?
2.1.2.2 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide
-
 Clostridium cylindrosporum tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?
2.1.2.2 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide
-
 Columba sp. tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?
2.1.2.2 inosinic acid + glycinamide ribotide + H2O
-
 Gallus gallus 5-amino-4-imidazolecarboxamide ribotide + formylglycinamide ribotide
-
 ?
2.1.2.2 additional information reaction does not occur if glycine, glycinamide or glycinamide riboside is substituted for glycinamide ribotide Gallus gallus ?
-
 ?
2.1.2.2 N5,N10-anhydroformyl-5,6,7,8tetrahydrofolic acid + 2-amino-N-ribosylacetamide 5'-phosphate + H2O
-
 Gallus gallus formylglycinamide ribotide + tetrahydrofolic acid + 2-formamido-N-ribosylacetamide 5'-phosphate
-
 ir
2.1.2.2 N5,N10-anhydroformyltetrahydrofolate + glycinamide ribotide + H2O
-
 Clostridium cylindrosporum N10-formyltetrahydrofolate + formylglycinamide ribotide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.2.2 2-amino-N-ribosylacetamide 5'-phosphate (glycinamide ribotide) transformylase
-
 Gallus gallus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.1.2.2 7.8
-
 Tris buffer, 38°C Gallus gallus