Any feedback?
Literature summary extracted from
- Malonyl-CoA decarboxylase from Streptomyces erythreus: purification, properties, and possible role in the production of erythromycin (1984), Arch. Biochem. Biophys., 229, 426-439.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.1.1.9 | acetyl-CoA | - |
Saccharopolyspora erythraea |  |
| 4.1.1.9 | butyryl-CoA | - |
Saccharopolyspora erythraea | |
| 4.1.1.9 | CoA | - |
Saccharopolyspora erythraea | |
| 4.1.1.9 | methylmalonyl-CoA | - |
Saccharopolyspora erythraea | |
| 4.1.1.9 | additional information | high ionic strength inhibits | Saccharopolyspora erythraea | |
| 4.1.1.9 | NEM | no inhibition | Saccharopolyspora erythraea | |
| 4.1.1.9 | p-hydroxymercuribenzoate | insensitive | Saccharopolyspora erythraea | |
| 4.1.1.9 | propionyl-CoA | - |
Saccharopolyspora erythraea | |
| 4.1.1.9 | SO42- | reversible | Saccharopolyspora erythraea | |
| 4.1.1.9 | succinyl-CoA | - |
Saccharopolyspora erythraea | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.1.1.9 | 0.143 | - |
malonyl-CoA | - |
Saccharopolyspora erythraea | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 4.1.1.9 | 45000 | - |
2 * 45000, SDS-PAGE | Saccharopolyspora erythraea |
| 4.1.1.9 | 93000 | - |
gel filtration | Saccharopolyspora erythraea |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.1.1.9 | Malonyl-CoA | Saccharopolyspora erythraea | the increase and decrease in the decarboxylase correlates with the rate of production of erythromycin, suggesting a possible role for this enzyme in the antibiotic production | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.1.1.9 | Saccharopolyspora erythraea | - |
- |
- |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 4.1.1.9 | 0.6 | - |
- |
Saccharopolyspora erythraea |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.1.1.9 | Malonyl-CoA | - |
Saccharopolyspora erythraea | Acetyl-CoA + CO2 | - |
? | |
| 4.1.1.9 | Malonyl-CoA | the increase and decrease in the decarboxylase correlates with the rate of production of erythromycin, suggesting a possible role for this enzyme in the antibiotic production | Saccharopolyspora erythraea | ? | - |
? | |
| 4.1.1.9 | methylmalonyl-CoA | the (R)-isomer is decarboxylated at 3% of the rate observed with malonyl-CoA, the (S)-isomer is not a substrate | Saccharopolyspora erythraea | propionyl-CoA + CO2 | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 4.1.1.9 | dimer | 2 * 45000, SDS-PAGE | Saccharopolyspora erythraea |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 4.1.1.9 | 5 | - |
- |
Saccharopolyspora erythraea |
pH Range
| EC Number | pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|---|
| 4.1.1.9 | 3.2 | 8.2 | about 30% of maximal activity at pH 3.2 and pH 8.2 | Saccharopolyspora erythraea |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
