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Literature summary extracted from

  • Walter, R.B.; Sung, H.M.; Intano, G.W.; Walter, C.A.
    Characterization of O6-methylguanine-DNA-methyltransferase (O6-MGMT) activity in Xiphophorus fishes (2001), Mutat. Res., 493, 11-22.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.63 6-O-benzylguanine competitive Xiphophorus couchianus
2.1.1.63 6-O-benzylguanine competitive Xiphophorus hellerii
2.1.1.63 6-O-benzylguanine competitive Xiphophorus maculatus

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.63 Xiphophorus couchianus
-
-
-
2.1.1.63 Xiphophorus hellerii
-
-
-
2.1.1.63 Xiphophorus maculatus
-
 Jp 163 A
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.63 brain
-
 Xiphophorus maculatus
-
2.1.1.63 brain
-
 Xiphophorus couchianus
-
2.1.1.63 brain
-
 Xiphophorus hellerii
-
2.1.1.63 gill
-
 Xiphophorus maculatus
-
2.1.1.63 gill
-
 Xiphophorus couchianus
-
2.1.1.63 gill
-
 Xiphophorus hellerii
-
2.1.1.63 liver
-
 Xiphophorus maculatus
-
2.1.1.63 liver
-
 Xiphophorus couchianus
-
2.1.1.63 liver
-
 Xiphophorus hellerii
-
2.1.1.63 testis
-
 Xiphophorus maculatus
-
2.1.1.63 testis
-
 Xiphophorus couchianus
-
2.1.1.63 testis
-
 Xiphophorus hellerii
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.63 DNA containing 6-O-methylguanine + [protein]-L-cysteine 6-O-methylguanine oligonucleotide Xiphophorus maculatus DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine
-
 ?
2.1.1.63 DNA containing 6-O-methylguanine + [protein]-L-cysteine 6-O-methylguanine oligonucleotide Xiphophorus couchianus DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine
-
 ?
2.1.1.63 DNA containing 6-O-methylguanine + [protein]-L-cysteine 6-O-methylguanine oligonucleotide Xiphophorus hellerii DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.1.1.63 23
-
-
 Xiphophorus maculatus

Temperature Range [°C]

EC Number Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
2.1.1.63 15 40 about 75% of maximal activity at 15° or at 40°C Xiphophorus maculatus

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
2.1.1.63 65
-
 5 min, almost complete inactivation Xiphophorus maculatus