EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.63 | DNA containing 6-O-methylguanine + [protein]-L-cysteine | Rattus norvegicus | the DNA repair enzyme can specifically remove methyl groups from 6-O-methylguanine, which is a major mutagenic and carcinogenic DNA lesion leading to the G-A transition | DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.1.1.63 | Rattus norvegicus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.1.1.63 | mammary tumor cell | no statistically significant difference in the amount of enzyme between tumors with and without activated H1-ras oncogene | Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.63 | DNA containing 6-O-methylguanine + [protein]-L-cysteine | - |
Rattus norvegicus | DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine | - |
? | |
2.1.1.63 | DNA containing 6-O-methylguanine + [protein]-L-cysteine | the DNA repair enzyme can specifically remove methyl groups from 6-O-methylguanine, which is a major mutagenic and carcinogenic DNA lesion leading to the G-A transition | Rattus norvegicus | DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine | - |
? |