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Literature summary extracted from

  • Durban, E.; Kim, S.; Jun, G.J.; Paik, W.K.
    Cytochrome c-specific protein-lysine methyltransferase from Neurospora crassa: kinetic mechanism (1983), Korean J. Biochem., 15, 19-24.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.59 S-adenosyl-L-homocysteine competitive versus S-adenosyl-L-methionine Neurospora crassa
2.1.1.59 S-adenosyl-L-methionine
-
 Neurospora crassa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.1.1.59 1.7
-
 [cytochrome c]-L-lysine
-
 Neurospora crassa
2.1.1.59 19
-
 S-adenosyl-L-methionine
-
 Neurospora crassa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.59 S-adenosyl-L-methionine + cytochrome c L-lysine Neurospora crassa
-
 S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.59 Neurospora crassa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.1.59
-
 Neurospora crassa

Reaction

EC Number Reaction Comment Organism Reaction ID
2.1.1.59 S-adenosyl-L-methionine + [cytochrome c]-L-lysine = S-adenosyl-L-homocysteine + [cytochrome c]-N6-methyl-L-lysine hybrid ping-pong mechanism Neurospora crassa
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.59 S-adenosyl-L-methionine + cytochrome c L-lysine
-
 Neurospora crassa S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
 ?
2.1.1.59 S-adenosyl-L-methionine + cytochrome c L-lysine horse heart cytochrome c-72 Neurospora crassa S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
 ?
2.1.1.59 S-adenosyl-L-methionine + [cytochrome c]-L-lysine
-
 Neurospora crassa S-adenosyl-L-homocysteine + [cytochrome c]-N6-methyl-L-lysine
-
 r

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.1.1.59 0.002
-
 S-adenosyl-L-methionine
-
 Neurospora crassa