EC Number | Cloned (Comment) | Organism |
---|---|---|
2.1.1.45 | - |
Homo sapiens |
EC Number | Crystallization (Comment) | Organism |
---|---|---|
2.1.1.45 | - |
Escherichia coli |
2.1.1.45 | - |
Lacticaseibacillus casei |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.1.1.45 | 5-fluoro-2'-deoxyuridylic acid | - |
Escherichia coli | |
2.1.1.45 | 5-fluoro-2'-deoxyuridylic acid | - |
Homo sapiens | |
2.1.1.45 | 5-fluoro-2'-deoxyuridylic acid | - |
Lacticaseibacillus casei | |
2.1.1.45 | 5-fluorouracil | - |
Escherichia coli | |
2.1.1.45 | 5-fluorouracil | - |
Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.45 | 5,10-methylenetetrahydrofolate + dUMP | Lacticaseibacillus casei | - |
dihydrofolate + dTMP | - |
? | |
2.1.1.45 | 5,10-methylenetetrahydrofolate + dUMP | Escherichia coli | biosynthesis of thymidylic acid, only de novo source of thymidine, crucial for DNA replication in every organism | dihydrofolate + dTMP | - |
? | |
2.1.1.45 | 5,10-methylenetetrahydrofolate + dUMP | Homo sapiens | biosynthesis of thymidylic acid, only de novo source of thymidine, crucial for DNA replication in every organism | dihydrofolate + dTMP | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.1.1.45 | Escherichia coli | - |
- |
- |
2.1.1.45 | Homo sapiens | - |
human colon tumor cell line HCT116/200-10 | - |
2.1.1.45 | Lacticaseibacillus casei | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.1.1.45 | - |
Homo sapiens |
2.1.1.45 | - |
Lacticaseibacillus casei |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.45 | 5,10-methylenetetrahydrofolate + dUMP | - |
Escherichia coli | dihydrofolate + dTMP | - |
r | |
2.1.1.45 | 5,10-methylenetetrahydrofolate + dUMP | - |
Homo sapiens | dihydrofolate + dTMP | - |
r | |
2.1.1.45 | 5,10-methylenetetrahydrofolate + dUMP | - |
Lacticaseibacillus casei | dihydrofolate + dTMP | - |
? | |
2.1.1.45 | 5,10-methylenetetrahydrofolate + dUMP | - |
Lacticaseibacillus casei | dihydrofolate + dTMP | - |
r | |
2.1.1.45 | 5,10-methylenetetrahydrofolate + dUMP | biosynthesis of thymidylic acid, only de novo source of thymidine, crucial for DNA replication in every organism | Escherichia coli | dihydrofolate + dTMP | - |
? | |
2.1.1.45 | 5,10-methylenetetrahydrofolate + dUMP | biosynthesis of thymidylic acid, only de novo source of thymidine, crucial for DNA replication in every organism | Homo sapiens | dihydrofolate + dTMP | - |
? | |
2.1.1.45 | additional information | - |
Escherichia coli | ? | - |
? | |
2.1.1.45 | additional information | - |
Lacticaseibacillus casei | ? | - |
? | |
2.1.1.45 | additional information | inhibitors targeted at human TS designed from structures of bacterial TS may not be optimal | Homo sapiens | ? | - |
? |
EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.1.1.45 | 37 | - |
no decrease in activity of recombinant enzymes up to | Homo sapiens |