Literature summary extracted from

Chen, D.H.; Daron, H.H.; Aull, J.L.
1-Phenyl-3-trimethylaminopropyl carbodiimide: a new inhibitor of thymidylate synthase (1992), J. Enzyme Inhib., 5, 259-268.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
2.1.1.45	1-ethyl-3-dimethylaminopropyl carbodiimide	-	Lacticaseibacillus casei
2.1.1.45	1-phenyl-3-(3-dimethylaminopropyl) carbodiimide	-	Lacticaseibacillus casei
2.1.1.45	1-phenyl-3-(3-trimethylaminopropyl) carbodiimide	-	Lacticaseibacillus casei

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2.1.1.45	5,10-methylenetetrahydrofolate + dUMP	Lacticaseibacillus casei	-	dihydrofolate + dTMP	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.1.1.45	Lacticaseibacillus casei	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.1.1.45	5,10-methylenetetrahydrofolate + dUMP	-	Lacticaseibacillus casei	dihydrofolate + dTMP	-	?
2.1.1.45	5,10-methylenetetrahydrofolate + dUMP	-	Lacticaseibacillus casei	dihydrofolate + dTMP	-	r

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Release 2023.1 (January 2023)