EC Number | Cloned (Comment) | Organism |
---|---|---|
2.1.1.45 | Escherichia coli transformed with a high amplifying expression plasmid containing the Escherichia coli thymidylate synthase gene | Escherichia coli |
EC Number | Crystallization (Comment) | Organism |
---|---|---|
2.1.1.45 | crystals of TS apoprotein grown using hanging drop method of vapor diffusion, cubic Laue group m3 with a = 133 A | Escherichia coli |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.1.1.45 | 5,10-methylenetetrahydrofolate | - |
Escherichia coli | |
2.1.1.45 | 5-fluoro-2'-deoxyuridylic acid | - |
Escherichia coli | |
2.1.1.45 | 5-fluoro-2'-deoxyuridylic acid | - |
Lacticaseibacillus casei | |
2.1.1.45 | 5-fluorouracil | - |
Escherichia coli |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
2.1.1.45 | 28000 | - |
2 * 28000, crystallographic studies | Escherichia coli |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.45 | 5,10-methylenetetrahydrofolate + dUMP | Escherichia coli | - |
dihydrofolate + dTMP | - |
? | |
2.1.1.45 | 5,10-methylenetetrahydrofolate + dUMP | Lacticaseibacillus casei | - |
dihydrofolate + dTMP | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.1.1.45 | Escherichia coli | - |
- |
- |
2.1.1.45 | Lacticaseibacillus casei | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.45 | 5,10-methylenetetrahydrofolate + dUMP | - |
Escherichia coli | dihydrofolate + dTMP | - |
? | |
2.1.1.45 | 5,10-methylenetetrahydrofolate + dUMP | - |
Escherichia coli | dihydrofolate + dTMP | - |
r | |
2.1.1.45 | 5,10-methylenetetrahydrofolate + dUMP | - |
Lacticaseibacillus casei | dihydrofolate + dTMP | - |
? | |
2.1.1.45 | 5,10-methylenetetrahydrofolate + dUMP | - |
Lacticaseibacillus casei | dihydrofolate + dTMP | - |
r |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.1.1.45 | dimer | - |
Lacticaseibacillus casei |
2.1.1.45 | dimer | 2 * 28000, crystallographic studies | Escherichia coli |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.1.1.45 | TS | - |
Escherichia coli |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.1.1.45 | (+)-methylenetetrahydrofolate | - |
Escherichia coli | |
2.1.1.45 | (+)-methylenetetrahydrofolate | - |
Lacticaseibacillus casei | |
2.1.1.45 | methenyltetrahydropteroylglutamate | - |
Escherichia coli |