EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.1.1.45 | 2'-deoxyuridine | - |
Rattus norvegicus | |
2.1.1.45 | 5-fluoro-2'-deoxyuridylic acid | - |
Homo sapiens | |
2.1.1.45 | 5-fluoro-2'-deoxyuridylic acid | - |
Lacticaseibacillus casei | |
2.1.1.45 | 5-fluoro-2'-deoxyuridylic acid | - |
Mus musculus | |
2.1.1.45 | 5-fluoro-2'-deoxyuridylic acid | - |
Rattus norvegicus | |
2.1.1.45 | 5-fluoro-2'-deoxyuridylic acid | - |
Saccharomyces cerevisiae | |
2.1.1.45 | dTMP | - |
Rattus norvegicus | |
2.1.1.45 | methopterin | - |
Homo sapiens | |
2.1.1.45 | methopterin | - |
Rattus norvegicus | |
2.1.1.45 | Procion blue | - |
Rattus norvegicus | |
2.1.1.45 | UDP-glucuronate | - |
Rattus norvegicus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.1.1.45 | 0.0068 | - |
2'-deoxyuridylate | - |
Rattus norvegicus | |
2.1.1.45 | 0.065 | - |
5,10-methylenetetrahydrofolate | - |
Rattus norvegicus |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
2.1.1.45 | 35000 | - |
2 * 35000, SDS-PAGE | Rattus norvegicus |
2.1.1.45 | 68000 | - |
gel filtration | Rattus norvegicus |
2.1.1.45 | 68000 | - |
gel filtration | Saccharomyces cerevisiae |
2.1.1.45 | 69000 | - |
Ehrlich ascites carcinoma cells | Mus musculus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.45 | 5,10-methylenetetrahydrofolate + dUMP | Mus musculus | - |
dihydrofolate + dTMP | - |
? | |
2.1.1.45 | 5,10-methylenetetrahydrofolate + dUMP | Homo sapiens | - |
dihydrofolate + dTMP | - |
? | |
2.1.1.45 | 5,10-methylenetetrahydrofolate + dUMP | Rattus norvegicus | - |
dihydrofolate + dTMP | - |
? | |
2.1.1.45 | 5,10-methylenetetrahydrofolate + dUMP | Saccharomyces cerevisiae | - |
dihydrofolate + dTMP | - |
? | |
2.1.1.45 | 5,10-methylenetetrahydrofolate + dUMP | Lacticaseibacillus casei | - |
dihydrofolate + dTMP | - |
? | |
2.1.1.45 | 5,10-methylenetetrahydrofolate + dUMP | Rattus norvegicus Wistar | - |
dihydrofolate + dTMP | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.1.1.45 | Homo sapiens | - |
neoplastic leukemic CCRF-CEM cells | - |
2.1.1.45 | Lacticaseibacillus casei | - |
- |
- |
2.1.1.45 | Mus musculus | - |
Ehrlich ascites carcinoma cells | - |
2.1.1.45 | Rattus norvegicus | - |
- |
- |
2.1.1.45 | Rattus norvegicus Wistar | - |
- |
- |
2.1.1.45 | Saccharomyces cerevisiae | - |
bakers' yeast | - |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.1.1.45 | - |
Rattus norvegicus |
2.1.1.45 | - |
Saccharomyces cerevisiae |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.1.1.45 | liver | - |
Mus musculus | - |
2.1.1.45 | liver | - |
Homo sapiens | - |
2.1.1.45 | liver | - |
Rattus norvegicus | - |
EC Number | Storage Stability | Organism |
---|---|---|
2.1.1.45 | 4°C, enzyme retains activity for about 3 weeks when stored with 20 mM dithiothreitol and 0.1 mM dUMP, without dithiothreitol purified enzyme is inactivated totally in 2 days, without dUMP enzyme keeps 50% activity after 1 week | Rattus norvegicus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.45 | (6S)-tetrahydropteroylglutamate + 2-deoxyuridylate | - |
Rattus norvegicus | 7,8-dihydropteroylglutamate + thymidine phosphate | - |
? | |
2.1.1.45 | (6S)-tetrahydropteroylglutamate + 2-deoxyuridylate | - |
Rattus norvegicus Wistar | 7,8-dihydropteroylglutamate + thymidine phosphate | - |
? | |
2.1.1.45 | 5,10-methylenetetrahydrofolate + dUMP | - |
Mus musculus | dihydrofolate + dTMP | - |
? | |
2.1.1.45 | 5,10-methylenetetrahydrofolate + dUMP | - |
Mus musculus | dihydrofolate + dTMP | - |
r | |
2.1.1.45 | 5,10-methylenetetrahydrofolate + dUMP | - |
Homo sapiens | dihydrofolate + dTMP | - |
? | |
2.1.1.45 | 5,10-methylenetetrahydrofolate + dUMP | - |
Homo sapiens | dihydrofolate + dTMP | - |
r | |
2.1.1.45 | 5,10-methylenetetrahydrofolate + dUMP | - |
Rattus norvegicus | dihydrofolate + dTMP | - |
? | |
2.1.1.45 | 5,10-methylenetetrahydrofolate + dUMP | - |
Rattus norvegicus | dihydrofolate + dTMP | - |
r | |
2.1.1.45 | 5,10-methylenetetrahydrofolate + dUMP | - |
Saccharomyces cerevisiae | dihydrofolate + dTMP | - |
? | |
2.1.1.45 | 5,10-methylenetetrahydrofolate + dUMP | - |
Saccharomyces cerevisiae | dihydrofolate + dTMP | - |
r | |
2.1.1.45 | 5,10-methylenetetrahydrofolate + dUMP | - |
Lacticaseibacillus casei | dihydrofolate + dTMP | - |
? | |
2.1.1.45 | 5,10-methylenetetrahydrofolate + dUMP | - |
Lacticaseibacillus casei | dihydrofolate + dTMP | - |
r | |
2.1.1.45 | 5,10-methylenetetrahydrofolate + dUMP | - |
Rattus norvegicus Wistar | dihydrofolate + dTMP | - |
? | |
2.1.1.45 | 5,10-methylenetetrahydrofolate + dUMP | - |
Rattus norvegicus Wistar | dihydrofolate + dTMP | - |
r |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.1.1.45 | dimer | - |
Mus musculus |
2.1.1.45 | dimer | - |
Homo sapiens |
2.1.1.45 | dimer | - |
Saccharomyces cerevisiae |
2.1.1.45 | dimer | - |
Lacticaseibacillus casei |
2.1.1.45 | dimer | 2 * 35000, SDS-PAGE | Rattus norvegicus |
2.1.1.45 | monomer | 1 * 69000, Ehrlich ascites carcinoma cells | Mus musculus |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.1.1.45 | 0.583 | - |
2'-deoxyuridine | - |
Rattus norvegicus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.1.1.45 | 7.3 | 8 | half-maximal activity at pH 6.3 | Rattus norvegicus |
EC Number | pH Stability | pH Stability Maximum | Comment | Organism |
---|---|---|---|---|
2.1.1.45 | 7 | 9 | 70% maximal activity at either pH 7.0 or 9.0, half-maximal activity at pH 6.3 | Rattus norvegicus |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.1.1.45 | 0.000005 | - |
5-fluoro-2'-deoxyuridylic acid | - |
Rattus norvegicus | |
2.1.1.45 | 0.0001 | - |
Procion blue | variable substrate 2'-deoxyuridine | Rattus norvegicus | |
2.1.1.45 | 0.00022 | - |
Procion blue | variable substrate 5,10-methylenetetrahydropteroylglutamate | Rattus norvegicus | |
2.1.1.45 | 0.023 | - |
methopterin | - |
Rattus norvegicus | |
2.1.1.45 | 0.07 | - |
dTMP | variable substrate 2'-deoxyuridine | Rattus norvegicus | |
2.1.1.45 | 0.073 | - |
methopterin | variable substrate 2'-deoxyuridine | Rattus norvegicus | |
2.1.1.45 | 0.24 | - |
dTMP | variable substrate 5,10-methylenetetrahydropteroylglutamate | Rattus norvegicus |