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Literature summary extracted from

  • Sani, B.P.; Vaid, A.; Cory, J.G.; Brockman, R.W.; Elliott, R.D.; Montgomery, J.A.
    5-Haloacetamido-5-deoxythymidines: novel inhibitors of thymidylate synthase (1986), Biochim. Biophys. Acta, 881, 175-184.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.1.1.45 medicine
-
Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.45 5-bromoacetamido-5'-deoxythymidine
-
Mus musculus
2.1.1.45 5-chloroacetamido-5'-deoxythymidine
-
Mus musculus
2.1.1.45 5-haloacetamido-5'-deoxythymidine
-
Mus musculus
2.1.1.45 5-iodoacetamido-5'-deoxythymidine
-
Mus musculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.1.1.45 0.0092
-
2'-deoxyuridylate
-
Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.45 5,10-methylenetetrahydrofolate + dUMP Mus musculus
-
dihydrofolate + dTMP
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.45 Mus musculus
-
L1210 cells
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.1.45
-
Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.45 5,10-methylenetetrahydrofolate + dUMP
-
Mus musculus dihydrofolate + dTMP
-
?
2.1.1.45 5,10-methylenetetrahydrofolate + dUMP
-
Mus musculus dihydrofolate + dTMP
-
r

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.1.1.45 0.0054
-
5-bromoacetamido-5'-deoxythymidine competitive inhibition Mus musculus
2.1.1.45 0.0066
-
5-bromoacetamido-5'-deoxythymidine
-
Mus musculus